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rs4713902

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) normal
(C;T) 0.69x decreased risk for bipolar disorder
(T;T) 0 0.47x decreased risk for bipolar disorder
ReferenceGRCh38 38.1/141
Chromosome6
Position35646249
GeneFKBP5
is asnp
is mentioned by
dbSNPrs4713902
ebirs4713902
HLIrs4713902
Exacrs4713902
Varsomers4713902
Maprs4713902
PheGenIrs4713902
hapmaprs4713902
1000 genomesrs4713902
hgdprs4713902
ensemblrs4713902
gopubmedrs4713902
geneviewrs4713902
scholarrs4713902
googlers4713902
pharmgkbrs4713902
gwascentralrs4713902
openSNPrs4713902
23andMers4713902
23andMe allrs4713902
SNP Nexus

SNPshotrs4713902
SNPdbers4713902
MSV3drs4713902
GWAS Ctlgrs4713902
GMAF0.2392
Max Magnitude0
? (C;C) (C;T) (T;T) 28
rs4713902, a SNP in the FKBP5 gene, is associated with increased risk for bipolar disorder in a study of 500+ Caucasian patients.

The most common allele, rs4713902(T), was associated with highest risk. Giving that allele a relative odds ratio of 1.0, the odds for the (C;T) and (C;C) genotypes were 0.69x (CI:0.55-0.88, p=0.001) and 0.47 (CI: 0.30-0.74, p=0.001).[PMID 18180755OA-icon.png]


[PMID 20090668OA-icon.png] Interaction of FKBP5, a Stress-Related Gene, with Childhood Trauma Increases the Risk for Attempting Suicide


[PMID 15637659OA-icon.png] Linkage disequilibrium patterns and tagSNP transferability among European populations.


[PMID 23274505OA-icon.png] Genetic association of FKBP5 and CRHR1 with cortisol response to acute psychosocial stress in healthy adults