|?|| (A;A) (A;G) (G;G) ||28|
, also known as SG13S89, is an ALOX5AP
gene SNP that has been defined as part of a haplotype potentially associated with risk for myocardial infarction
or ischemic stroke
. Details of this haplotype and several related studies are on the ALOX5AP
[PMID 17387518] Association of ALOX5AP with ischemic stroke: a population-based case-control study.
[PMID 19130089] Genetic effects in the leukotriene biosynthesis pathway and association with atherosclerosis.
[PMID 20592751] Human lipoxygenase pathway gene variation and association with markers of subclinical atherosclerosis in the diabetes heart study.
[PMID 24368493] Interaction between ALOX5AP and CYP3A5 gene variants significantly increases the risk for cerebral infarctions in Chinese
[PMID 25902778] Impact of inflammation, gene variants, and cigarette smoking on coronary artery disease risk
[PMID 26885075] A tagging ALOX5AP polymorphism and risk of ischemic stroke in a northeastern Chinese Han population.
[PMID 26944113] Arachidonate 5-lipoxygenase (ALOX5) gene polymorphism is associated with Alzheimer's disease and body mass index.