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rs4774

From SNPedia

Orientationplus
Stabilizedplus
Make rs4774(C;C)
Make rs4774(C;G)
Make rs4774(G;G)
ReferenceGRCh38 38.1/141
Chromosome16
Position10906991
GeneCIITA
is asnp
is mentioned by
dbSNPrs4774
ebirs4774
HLIrs4774
Exacrs4774
Varsomers4774
Maprs4774
PheGenIrs4774
hapmaprs4774
1000 genomesrs4774
hgdprs4774
ensemblrs4774
gopubmedrs4774
geneviewrs4774
scholarrs4774
googlers4774
pharmgkbrs4774
gwascentralrs4774
openSNPrs4774
23andMers4774
23andMe allrs4774
SNP Nexus

SNPshotrs4774
SNPdbers4774
MSV3drs4774
GWAS Ctlgrs4774
GMAF0.2622
Max Magnitude
? (C;C) (C;G) (G;G) 28

[PMID 19317741] Autoimmune disease association signals in CIITA and KIAA0350 are not involved in celiac disease susceptibility


[PMID 22272574] Influence of MHCIITA rs3087456 and rs4774 polymorphisms in the susceptibility to cardiovascular disease of patients with rheumatoid arthritis


[PMID 22461888OA-icon.png] Interaction Analysis between HLA-DRB1 Shared Epitope Alleles and MHC Class II Transactivator CIITA Gene with Regard to Risk of Rheumatoid Arthritis


[PMID 17012290OA-icon.png] Role of the MHC2TA gene in autoimmune diseases.


[PMID 17678724] Environment-gene interaction in multiple sclerosis: human herpesvirus 6 and MHC2TA.


[PMID 19221398] Chromosomal region 16p13: further evidence of increased predisposition to immune diseases.


[PMID 19659749] MHC2TA rs4774C and HHV-6A active replication in multiple sclerosis patients.


[PMID 20211854OA-icon.png] CIITA variation in the presence of HLA-DRB1*1501 increases risk for multiple sclerosis.


[PMID 21962857] Herpesvirus active replication in multiple sclerosis a genetic control?


GET Evidence
CIITA-G500A
aa_change Gly500Ala
aa_change_short G500A
impact not reviewed
qualified_impact Insufficiently evaluated not reviewed
overall_frequency 0.280071
summary



[PMID 23489895] CIITA rs4774 and rs6498122 polymorphisms are associated with oral lichen planus in Chinese people: a case-control study


[PMID 23777927] Both qualitative and quantitative genetic variation of MHC class II molecules may influence susceptibility to autoimmune diseases: the case of endemic pemphigus foliaceus.


[PMID 25992516] The CIITA genetic polymorphism rs4774*C in combination with the HLA-DRB1*15:01 allele as a putative susceptibility factor to multiple sclerosis in Brazilian females