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rs4795400

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) normal
(C;T) normal
(T;T) 0 if 4 years old or younger, ~2.5x increased asthma risk if exposed to smoke
ReferenceGRCh38 38.1/141
Chromosome17
Position39910767
GeneGSDMB
is asnp
is mentioned by
dbSNPrs4795400
ebirs4795400
HLIrs4795400
Exacrs4795400
Varsomers4795400
Maprs4795400
PheGenIrs4795400
hapmaprs4795400
1000 genomesrs4795400
hgdprs4795400
ensemblrs4795400
gopubmedrs4795400
geneviewrs4795400
scholarrs4795400
googlers4795400
pharmgkbrs4795400
gwascentralrs4795400
openSNPrs4795400
23andMers4795400
23andMe allrs4795400
SNP Nexus

SNPshotrs4795400
SNPdbers4795400
MSV3drs4795400
GWAS Ctlgrs4795400
GMAF0.3315
Max Magnitude0
? (C;C) (C;T) (T;T) 28
rs4795400 is one of several SNPs from a region on chromosome 17q21 that has been linked to risk for asthma.

A total of 651 French patients with asthma, from among 1,621 subjects in 388 families, were analyzed for SNPs in the (17q21) region. An association was found between this SNP and early-onset asthma (but not with later onset asthma) which was significant after correction at p < 0.001. Upon further study, this association was seen primarily only in children exposed to tobacco smoke. The odds ratio was 2.5, based on the most likely assumption that this risk is associated only with the recessive homozygous state (and not the heterozygous state, which is still possible). [PMID 18923164]


OMIM611403
Desc
Variant
Relatedalso


[PMID 22370936] Genetic variants on 17q21 are associated with asthma in a Han Chinese population


GET Evidence
rs4795400
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.296875
summary