Have questions? Visit https://www.reddit.com/r/SNPedia

rs4796793

From SNPedia

Orientationplus
Stabilizedplus
Make rs4796793(C;C)
Make rs4796793(C;G)
Make rs4796793(G;G)
ReferenceGRCh38 38.1/141
Chromosome17
Position42390192
GeneSTAT3
is asnp
is mentioned by
dbSNPrs4796793
ebirs4796793
HLIrs4796793
Exacrs4796793
Varsomers4796793
Maprs4796793
PheGenIrs4796793
hapmaprs4796793
1000 genomesrs4796793
hgdprs4796793
ensemblrs4796793
gopubmedrs4796793
geneviewrs4796793
scholarrs4796793
googlers4796793
pharmgkbrs4796793
gwascentralrs4796793
openSNPrs4796793
23andMers4796793
23andMe allrs4796793
SNP Nexus

SNPshotrs4796793
SNPdbers4796793
MSV3drs4796793
GWAS Ctlgrs4796793
GMAF0.3411
Max Magnitude
? (C;C) (C;G) (G;G) 28
rs4796793, a SNP in the 5' region of the signal transducer and activator 3 STAT3 gene, has been linked in a study of 75 Japanese patients to (successful) response to interferon-alpha immunotherapy for metastatic kidney cancer. [PMID 17602083]

From this paper [PMID 17602083]:

"... rs4796793 was the most significant predictor of IFN-alpha response (odds ratio [OR] = 2.73; 95% CI, 1.38 to 5.78). The highest OR was shown in the (C;C) genotype ... compared to the (G;G) + (G;C) genotypes (OR = 8.38, 95% CI, 1.63 to 42.96)."



[PMID 19604093OA-icon.png] Genetic polymorphisms, their allele combinations and IFN-beta treatment response in Irish multiple sclerosis patients.


[PMID 21948258] Association between polymorphisms in the signal transducer and activator of transcription and dilated cardiomyopathy in the Chinese Han population.


GET Evidence
rs4796793
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.625
summary



[PMID 24781989] Association between STAT3 gene polymorphisms and ulcerative colitis susceptibility: a case-control study in the Chinese Han population


[PMID 25973100OA-icon.png] STAT3 and STAT5b polymorphism contributes to breast cancer risk and clinical outcomes