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rs4818

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;G)
Make rs4818(C;C)
Make rs4818(G;G)
ReferenceGRCh38 38.1/141
Chromosome22
Position19963684
GeneCOMT, MIR4761
is asnp
is mentioned by
dbSNPrs4818
ebirs4818
HLIrs4818
Exacrs4818
Varsomers4818
Maprs4818
PheGenIrs4818
hapmaprs4818
1000 genomesrs4818
hgdprs4818
ensemblrs4818
gopubmedrs4818
geneviewrs4818
scholarrs4818
googlers4818
pharmgkbrs4818
gwascentralrs4818
openSNPrs4818
23andMers4818
23andMe allrs4818
SNP Nexus

SNPshotrs4818
SNPdbers4818
MSV3drs4818
GWAS Ctlgrs4818
GMAF0.3232
Max Magnitude
Seems to play a role in the brain

This is a synonymous change. it does not affect the amino acid.

Neighborrs6267
Distance944
Neighborrs4680
Distance64
Neighborrs17849308
Distance63

[PMID 19367610] Gender-specific COMT Val158Met polymorphism association in Spanish schizophrenic patients

[PMID 19290789] Association studies of catechol-O-methyltransferase (COMT) gene with schizophrenia and response to antipsychotic treatment

[PMID 19551860] Common germline polymorphisms in COMT, CYP19A1, ESR1, PGR, SULT1E1 and STS and survival after a diagnosis of breast cancer

OMIM116790
DescCATECHOL-O-METHYLTRANSFERASE; COMT
Variant
Relatedalso
[PMID 19605537OA-icon.png] Effects of Catechol-O-Methyltransferase on Normal Variation in the Cognitive Function of Children

[PMID 19699472] Tolcapone Effects on Gating, Working Memory, and Mood Interact with the Synonymous Catechol-O-methyltransferase rs4818C/G Polymorphism



[PMID 20570835] No evidence for a role of the catechol-O-methyltransferase pain sensitivity haplotypes in chronic widespread pain

[PMID 21120493] Influence of catechol-O-methyltransferase (COMT) gene polymorphisms in pain sensibility of Brazilian fibromialgia patients


[PMID 21300128] COMT Val158met variant and functional haplotypes associated with childhood ADHD history in women with bulimia nervosa


[PMID 21940152] The impact of COMT gene polymorphisms on suicidality in treatment resistant major depressive disorder - A European Multicenter Study


[PMID 22451510] Catechol-O-Methyltransferase Gene and Executive Function in Children With ADHD


[PMID 22528689] Pain sensitivity in fibromyalgia is associated with catechol-O-methyltransferase (COMT) gene


[PMID 10709220OA-icon.png] Through the Looking Glass: Differential Noradenergic Modulation of Prefrontal Cortical Function


[PMID 22178088OA-icon.png] Catechol-O-methyltransferase (COMT) single nucleotide polymorphisms and haplotypes are not major risk factors for polycystic ovary syndrome

[PMID 15290009] Differential expression of human COMT alleles in brain and lymphoblasts detected by RT-coupled 5' nuclease assay.


[PMID 16026601OA-icon.png] Decision forest analysis of 61 single nucleotide polymorphisms in a case-control study of esophageal cancer; a novel method.


[PMID 16816940] Direct molecular haplotyping of multiple polymorphisms within exon 4 of the human catechol-O-methyltransferase gene by liquid chromatography-electrospray ionization time-of-flight mass spectrometry.


[PMID 16848906OA-icon.png] Genetic polymorphisms in monoamine neurotransmitter systems show only weak association with acute post-surgical pain in humans.


[PMID 17135598] No evidence for a major role of polymorphisms during bupropion treatment.


[PMID 17961261OA-icon.png] Catechol-O-methyltransferase gene haplotypes in Mexican and Spanish patients with fibromyalgia.


[PMID 17994190] Norepinephrine transporter and catecholamine-O-methyltransferase gene variants and attention-deficit/hyperactivity disorder symptoms in adults.


[PMID 18037454] Planning, decision-making and the COMT rs4818 polymorphism in healthy males.


[PMID 18324659] COMT polymorphisms affecting protein expression are risk factors for endometrial cancer.


[PMID 18574484OA-icon.png] The complex global pattern of genetic variation and linkage disequilibrium at catechol-O-methyltransferase.


[PMID 18698234] The association of functional catechol-O-methyltransferase haplotypes with risk of Parkinson's disease, levodopa treatment response, and complications.


[PMID 18802928] Association between catechol O-methyltransferase (COMT) haplotypes and severity of hyperactivity symptoms in adults.


[PMID 19094200OA-icon.png] Genetic variation in the catechol-O-methyltransferase (COMT) gene and morphine requirements in cancer patients with pain.


[PMID 19168589OA-icon.png] Variants in hormone-related genes and the risk of biliary tract cancers and stones: a population-based study in China.


[PMID 19365560OA-icon.png] Low enzymatic activity haplotypes of the human catechol-O-methyltransferase gene: enrichment for marker SNPs.


[PMID 19693267OA-icon.png] Financial and psychological risk attitudes associated with two single nucleotide polymorphisms in the nicotine receptor (CHRNA4) gene.


[PMID 20531207] The impact of catechol-O-methyltransferase SNPs and haplotypes on treatment response phenotypes in major depressive disorder: a case-control association study.


[PMID 20627703] The association of single nucleotide polymorphisms in the catechol-O-methyltransferase gene and pain scores in female patients with major depressive disorder.


[PMID 20842020] Catecholamine-o-methyltransferase polymorphisms are associated with postoperative pain intensity.


[PMID 20863768] Association of catechol-O-methyltransferase genetic variants with outcome in patients undergoing surgical treatment for lumbar degenerative disc disease.


[PMID 21304959OA-icon.png] Epistasis between COMT and MTHFR in maternal-fetal dyads increases risk for preeclampsia.


[PMID 21423693OA-icon.png] Effect sizes in experimental pain produced by gender, genetic variants and sensitization procedures.


[PMID 21462137] [An association study of COMT gene polymorphisms with schizophrenia].


[PMID 21680027] Influence and interaction of genetic polymorphisms in catecholamine neurotransmitter systems and early life stress on antidepressant drug response.


[PMID 22354729OA-icon.png] Association of catechol-O-methyltransferase gene polymorphisms with schizophrenia and negative symptoms in a Chinese population.


GET Evidence
rs4818
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.325865
summary



[PMID 23872233] The relationship between the presence of ADHD and certain candidate gene polymorphisms in a Turkish sample


[PMID 24448899] Metabolic syndrome in patients taking clozapine: prevalence and influence of catechol-O-methyltransferase genotype


[PMID 22718527OA-icon.png] The associations between OPRM 1 and COMT genotypes and postoperative pain, opioid use, and opioid-induced sedation.


[PMID 22890010] Association of COMT, MTHFR, and SLC19A1(RFC-1) polymorphisms with homocysteine blood levels and cognitive impairment in Parkinson's disease.


[PMID 23178897OA-icon.png] The catechol-O-methyltransferase gene (COMT) and cognitive function from childhood through adolescence.


[PMID 24593143OA-icon.png] Genetic polymorphisms of catechol-O-methyltransferase modify the neurobehavioral effects of mercury in children


[PMID 25636089] [Polymorphisms of catechol-O-methyltransferase and monoamine oxidase B genes among Chinese patients with Parkinson's disease]


[PMID 26849490] Association between catechol-O-methyl transferase gene polymorphisms and fibromyalgia in a Korean population: A case-control study.


[PMID 27228319] A Tetra-Primer Amplification Refractory System Technique for the Cost-Effective and Novel Genotyping of Eight Single-Nucleotide Polymorphisms of the Catechol-O-Methyltransferase Gene.