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rs4819756

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;G) 0
Make rs4819756(A;A)
Make rs4819756(G;G)
ReferenceGRCh38 38.1/141
Chromosome22
Position18925165
GenePRODH
is asnp
is mentioned by
dbSNPrs4819756
ebirs4819756
HLIrs4819756
Exacrs4819756
Varsomers4819756
Maprs4819756
PheGenIrs4819756
hapmaprs4819756
1000 genomesrs4819756
hgdprs4819756
ensemblrs4819756
gopubmedrs4819756
geneviewrs4819756
scholarrs4819756
googlers4819756
pharmgkbrs4819756
gwascentralrs4819756
openSNPrs4819756
23andMers4819756
23andMe allrs4819756
SNP Nexus

SNPshotrs4819756
SNPdbers4819756
MSV3drs4819756
GWAS Ctlgrs4819756
GMAF0.2571
Max Magnitude0
? (A;A) (A;G) (G;G) 28

plos ([PMID 18989458OA-icon.png]) - The minor alleles of rs4819756 and rs2870983 were significantly negatively associated with schizophrenia


Venter snp
Source plos
Gene PRODH
allele G
frequency
sift AFFECT FUNCTION
HuRef 1103691005874
Disease Association Defects in PRODH are the cause of type I hyperprolinaemia (MIM:239500). It is a disorder characterized by elevated serum proline levels. May be involved in the psychiatric and behavioral phenotypes associated in the 22q11 velocardiofacial syndrome.



[PMID 19693005OA-icon.png] Executive function, neural circuitry, and genetic mechanisms in schizophrenia.


GET Evidence
PRODH-W77R
aa_change Trp77Arg
aa_change_short W77R
impact not reviewed
qualified_impact Insufficiently evaluated not reviewed
overall_frequency
summary



[PMID 24853458] Association of COMT and PRODH gene variants with intelligence quotient (IQ) and executive functions in 22q11.2DS subjects