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rs4821544

From SNPedia

Orientationplus
Stabilizedplus
Make rs4821544(C;C)
Make rs4821544(C;T)
Make rs4821544(T;T)
ReferenceGRCh38 38.1/141
Chromosome22
Position36862461
GeneNCF4
is asnp
is mentioned by
dbSNPrs4821544
ebirs4821544
HLIrs4821544
Exacrs4821544
Varsomers4821544
Maprs4821544
PheGenIrs4821544
hapmaprs4821544
1000 genomesrs4821544
hgdprs4821544
ensemblrs4821544
gopubmedrs4821544
geneviewrs4821544
scholarrs4821544
googlers4821544
pharmgkbrs4821544
gwascentralrs4821544
openSNPrs4821544
23andMers4821544
23andMe allrs4821544
SNP Nexus

SNPshotrs4821544
SNPdbers4821544
MSV3drs4821544
GWAS Ctlgrs4821544
GMAF0.3214
Max Magnitude
? (C;C) (C;T) (T;T) 28
Rs4821544
PubMed [PMID 17435756OA-icon.png]
Affy Probeset SNP_A-2222922
Affy Orientation same
On GW 5.0 1
Alleles A/B C/T
Ancestral C
Population EU
Allele C
Case Freq. 0.4
Control Freq. 0.33
Odds Ratio Het
Odds Ratio Hom
Odds Ratio All 1.19
Disease Crohn's disease (CD)


A study of 507 CD patients, 475 UC patients and 576 controls from New Zealand Caucasians found that rs4821544, a SNP in the NCF4 gene, was associated specifically with ileal Crohn's disease but not with other forms of inflammatory bowel disease. The reported odds ratio was 1.425, CI: 1.092-1.859, p=0.009.[PMID 18580884]

rs4821544 increases susceptibility to Crohn's disease 1.19 times for carriers of the C allele [PMID 17435756OA-icon.png]


[PMID 19262523] rs224136 on chromosome 10q21.1 and variants in PHOX2B, NCF4, and FAM92B are not major genetic risk factors for susceptibility to Crohn's disease in the German population

OMIM266600
DescINFLAMMATORY BOWEL DISEASE 1; IBD1
Variant
Relatedalso


[PMID 22115380] Prediction of disease complication occurrence in Crohn's disease using phenotype and genotype parameters at diagnosis

GWAS snp
PMID [PMID 22197932OA-icon.png]
Trait
Title Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis.
Risk Allele C
P-val 0.000006
Odds Ratio 1.0900 None


[PMID 17068223OA-icon.png] A genome-wide association study identifies IL23R as an inflammatory bowel disease gene.