|| 0.75x decreased risk for Non-hodgkin's lymphoma
|| 0.74x decreased risk for Non-hodgkin's lymphoma
|?|| (A;A) (A;C) (C;C) ||28|
is a SNP located in a cluster of toll-like receptor genes.
In a pooled analysis including three population-based case-control studies of Non-Hodgkin's lymphoma (1,946 cases, 1,808 controls), two SNPs in moderate linkage disequilibrium were significantly associated with NHL: rs10008492 (odds ratio for (C;T) genotype 1.12, CI: 0.97-1.30; OR(T;T) 1.40, CI: 1.15-1.71; p(trend)=0.001) and rs4833103 (OR(A;C) 0.75, CI: 0.64-0.88; OR(A;A) 0.74, CI: 0.62-0.90; p(trend)=0.002; p(dominant)=0.0002).[PMID 19029192]
[PMID 19307593] Signals of recent positive selection in a worldwide sample of human populations.
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[PMID 21872627] Association of polymorphisms in TLR genes and in genes of the Toll-like receptor signaling pathway with cancer risk.
[PMID 23815888] Inference of human continental origin and admixture proportions using a highly discriminative ancestry informative 41-SNP panel.