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rs4845622

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) normal
(A;C) 1.7x increased melanoma risk
(C;C) normal?
ReferenceGRCh38 38.1/141
Chromosome1
Position154438943
GeneIL6R
is asnp
is mentioned by
dbSNPrs4845622
ebirs4845622
HLIrs4845622
Exacrs4845622
Varsomers4845622
Maprs4845622
PheGenIrs4845622
hapmaprs4845622
1000 genomesrs4845622
hgdprs4845622
ensemblrs4845622
gopubmedrs4845622
geneviewrs4845622
scholarrs4845622
googlers4845622
pharmgkbrs4845622
gwascentralrs4845622
openSNPrs4845622
23andMers4845622
23andMe allrs4845622
SNP Nexus

SNPshotrs4845622
SNPdbers4845622
MSV3drs4845622
GWAS Ctlgrs4845622
GMAF0.3196
Max Magnitude
? (A;A) (A;C) (C;C) 28
A study of 219 female melanoma patients and an equal number of controls concluded that 4 linked SNPs within the IL6R gene were associated with increased melanoma risk, but only when heterozygous. The odds ratio associated with the minor allele of this SNP, rs4845622, was 1.69 (CI: 1.03-2.75). The 4 linked SNPs from identified in this study are: rs6684439, rs4845618, rs4845622, and rs8192284.[PMID 18781131OA-icon.png]


[PMID 18852330OA-icon.png] Interleukin-6 receptor gene, plasma C-reactive protein, and diabetes risk in women.