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rs4846914

From SNPedia

Orientationplus
Stabilizedplus
Make rs4846914(A;A)
Make rs4846914(A;G)
Make rs4846914(G;G)
ReferenceGRCh38 38.1/141
Chromosome1
Position230159944
GeneGALNT2
is asnp
is mentioned by
dbSNPrs4846914
ebirs4846914
HLIrs4846914
Exacrs4846914
Varsomers4846914
Maprs4846914
PheGenIrs4846914
hapmaprs4846914
1000 genomesrs4846914
hgdprs4846914
ensemblrs4846914
gopubmedrs4846914
geneviewrs4846914
scholarrs4846914
googlers4846914
pharmgkbrs4846914
gwascentralrs4846914
openSNPrs4846914
23andMers4846914
23andMe allrs4846914
SNP Nexus

SNPshotrs4846914
SNPdbers4846914
MSV3drs4846914
GWAS Ctlgrs4846914
GMAF0.3673
Max Magnitude
? (A;A) (A;G) (G;G) 28
GWAS
SNP rs4846914
PubMedID [PMID 18193044OA-icon.png]
Condition Triglycerides
Gene GALNT2
Risk Allele G
pValue 7.00E-015
OR 0.08
95% CI 0.06-0.10) % SD highe


Neighborrs2144300
Distance775
GWAS snp
PMID [PMID 19060906OA-icon.png]
Trait HDL cholesterol
Title Common variants at 30 loci contribute to polygenic dyslipidemia
Risk Allele G
P-val 4E-8
Odds Ratio 0.05 [0.01-0.09] SD decrease



[PMID 19656773OA-icon.png] A polygenic basis for four classical Fredrickson hyperlipoproteinemia phenotypes that are characterized by hypertriglyceridemia



The G allele of rs4846914 is associated with higher risk of hypertriglyceridemia. [PMID 18596051]]


[PMID 21933382OA-icon.png] Association of the GALNT2 gene polymorphisms and several environmental factors with serum lipid levels in the Mulao and Han populations

GWAS snp
PMID [PMID 20686565OA-icon.png]
Trait
Title Biological, clinical and population relevance of 95 loci for blood lipids.
Risk Allele G
P-val 4E-21
Odds Ratio 0.6100 None


[PMID 18852197OA-icon.png] Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants.


[PMID 18987386] Polymorphisms at newly identified lipid-associated loci are associated with blood lipids and cardiovascular disease in an Asian Malay population.


[PMID 19041386OA-icon.png] Genetic-epidemiological evidence on genes associated with HDL cholesterol levels: a systematic in-depth review.


[PMID 19060910OA-icon.png] Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.


[PMID 19197348OA-icon.png] Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.


[PMID 19299407OA-icon.png] Replication of genetic associations with plasma lipoprotein traits in a multiethnic sample.


[PMID 19951432OA-icon.png] Analysis of recently identified dyslipidemia alleles reveals two loci that contribute to risk for carotid artery disease.


[PMID 20158509] Triglyceride level modifying functional variants of GALTN2 and MLXIPL in patients with ischaemic stroke.


[PMID 20160193OA-icon.png] Investigation of variants identified in caucasian genome-wide association studies for plasma high-density lipoprotein cholesterol and triglycerides levels in Mexican dyslipidemic study samples.


[PMID 20385826OA-icon.png] Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC).


GET Evidence
rs4846914
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.3125
summary



GWAS snp
PMID [PMID 24097068OA-icon.png]
Trait HDL cholesterol
Title Discovery and refinement of loci associated with lipid levels.
Risk Allele G
P-val 4E-41
Odds Ratio .05 [NR] unit decrease


[PMID 26405973] Gene environment interaction of GALNT2 and APOE gene with hypertension in the Chinese Han Population