|| 2.5x increased risk of Azheimer's and decreased age at onset
|?|| (A;A) (A;G) (G;G) ||28|
increases susceptibility to Alzheimer's disease
2.56 times for (A;A) homozygotes [PMID 10976648
[PMID 18855268] systolic blood pressure increased with rs4934(A)
| Disease Association
|| Defects in SERPINA3 may be a cause of chronic obstructive pulmonary disease (COPD) (MIM:107280).
[PMID 21067581] finds no association between rs4934 and pulmonary emphysema
[PMID 19907165] Polymorphism rs4934 of SERPINA3 and Sporadic Intracranial Aneurysms in the Chinese Population
[PMID 16617143] Algorithm for automatic genotype calling of single nucleotide polymorphisms using the full course of TaqMan real-time data.
[PMID 17054776] The genetics of chronic obstructive pulmonary disease.
[PMID 19390575] Lung cancer susceptibility model based on age, family history and genetic variants.
|| not reviewed
|| Insufficiently evaluated not reviewed