| Geno
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Mag
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Summary
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| (T;T)
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1
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Most common genotype in several populations; yet also higher leadership occupancy?
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One paper published in 2013 (and not replicated since then to our knowledge), titled "Born to Lead? A Twin Design and Genetic Association Study of Leadership Role Occupancy", performed a GWAS study that concluded that leadership role occupancy is associated with rs4950, a SNP in the neuronal acetylcholine receptor gene (CHRNB3). Individuals with the rs4950(T;T) genotype (as oriented in dbSNP and SNPedia) are statistically more likely (odds ratio ~1.5) to occupy leadership positions as compared to rs4950(C;T) or (C;C) individuals.[PMID 23459689
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Popular news about this finding includes:
http://www.sciencedaily.com/releases/2013/01/130115111553.htm and
https://www.23andme.com/you/community/thread/16689/
[PMID 18055561] The neuronal nicotinic receptor subunit genes (CHRNA6 and CHRNB3) are associated with subjective responses to tobacco.
[PMID 18571741] Genetic variability in nicotinic acetylcholine receptors and nicotine addiction: converging evidence from human and animal research.
[PMID 18704094] Genetic association of the CHRNA6 and CHRNB3 genes with tobacco dependence in a nationally representative sample.
[PMID 19259974] Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes.
[PMID 19492010] The genetic components of alcohol and nicotine co-addiction: from genes to behavior.
[PMID 19500157] SNPs in CHRNA6 and CHRNB3 are associated with alcohol consumption in a nationally representative sample.
[PMID 31942417] Chronic Obstructive Pulmonary Disease Risk and Smoking Cessation Changes Induced by CHRNA5-A3 and CHRNB3-A6 Variation in a Chinese Male Population.
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