Have questions? Visit https://www.reddit.com/r/SNPedia

rs4986910

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(C;C) CYP3A4*3 homozygote
(C;T) carrier of one CYP3A4*3 allele
(T;T) 0 normal
ReferenceGRCh38 38.1/141
Chromosome7
Position99760901
GeneCYP3A4
is asnp
is mentioned by
dbSNPrs4986910
ebirs4986910
HLIrs4986910
Exacrs4986910
Varsomers4986910
Maprs4986910
PheGenIrs4986910
hapmaprs4986910
1000 genomesrs4986910
hgdprs4986910
ensemblrs4986910
gopubmedrs4986910
geneviewrs4986910
scholarrs4986910
googlers4986910
pharmgkbrs4986910
gwascentralrs4986910
openSNPrs4986910
23andMers4986910
23andMe allrs4986910
SNP Nexus

SNPshotrs4986910
SNPdbers4986910
MSV3drs4986910
GWAS Ctlgrs4986910
GMAF0.003214
Max Magnitude0
? (C;C) (C;T) (T;T) 28
rs4986910, also known as 1334T>C, 23171T>C or M445T, is a SNP in the CYP3A4 gene.

The rs4986910(C) allele defines the CYP3A4*3 variant.



[PMID 19214745OA-icon.png] Polymorphisms in estrogen biosynthesis and metabolism-related genes, ionizing radiation exposure, and risk of breast cancer among US radiologic technologists



[PMID 17615053OA-icon.png] Polymorphisms in the cytochrome P450 genes CYP1A2, CYP1B1, CYP3A4, CYP3A5, CYP11A1, CYP17A1, CYP19A1 and colorectal cancer risk.


[PMID 19076156OA-icon.png] Polymorphisms of drug-metabolizing enzymes (GST, CYP2B6 and CYP3A) affect the pharmacokinetics of thiotepa and tepa.


GET Evidence
CYP3A4-M445T
aa_change Met445Thr
aa_change_short M445T
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.0056702
summary