Have questions? Visit https://www.reddit.com/r/SNPedia


From SNPedia

Make rs5015480(C;C)
Make rs5015480(C;T)
Make rs5015480(T;T)
ReferenceGRCh38 38.1/142
is asnp
is mentioned by
1000 genomesrs5015480
23andMe allrs5015480
SNP Nexus

GWAS Ctlgrs5015480
Max Magnitude
? (C;C) (C;T) (T;T) 28
[PMID 17928989] associated with type-2 diabetes, but then called into question by 10.1371/journal.pbio.1000294 along with rs9300039 rs4402960 rs7754840 rs17044137 rs11037909 rs1081161 rs1111875 rs7923837 rs12885713 rs1219648 rs2981582
SNP rs5015480
PubMedID [PMID 17463249OA-icon.png]
Condition Type 2 diabetes
Risk Allele C
pValue 6.00E-010
OR 1.13
95% CI 1.08-1.17

GWAS snp
PMID [PMID 18372903OA-icon.png]
Trait Type 2 diabetes
Title Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
Risk Allele C
P-val 7.0000000000000005E-8
Odds Ratio 1.17 [1.11-1.24]

[PMID 19622614] HHEX-IDE polymorphism is associated with low birth weight in offspring with a family history of type 1 diabetes

[PMID 20503258] Candidate gene association study conditioning on individual ancestry in patients with type 2 diabetes and metabolic syndrome from Mexico City

GWAS snp
PMID [PMID 20581827OA-icon.png]
Trait Type 2 diabetes
Title Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
Risk Allele C
P-val 1E-15
Odds Ratio 1.18 [1.13-1.23]
GWAS snp
PMID [PMID 20862305OA-icon.png]
Title Identification of new genetic risk variants for type 2 diabetes
Risk Allele C
P-val 0.000009
Odds Ratio 1.17 [1.11-1.24]

[PMID 22558147OA-icon.png] Lack of Association of Type 2 Diabetes Susceptibility Genotypes and Body Weight on the Development of Islet Autoimmunity and Type 1 Diabetes

[PMID 17786212OA-icon.png] Heterogeneity in meta-analyses of genome-wide association investigations.

[PMID 18426861OA-icon.png] Association analysis of type 2 diabetes Loci in type 1 diabetes.

[PMID 18443202OA-icon.png] Association analysis in african americans of European-derived type 2 diabetes single nucleotide polymorphisms from whole-genome association studies.

[PMID 18469204OA-icon.png] Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians.

[PMID 18633108OA-icon.png] Common variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/IDE genes are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population.

[PMID 19002430] Type 2 diabetes-associated genetic variants discovered in the recent genome-wide association studies are related to gestational diabetes mellitus in the Korean population.

[PMID 19056611OA-icon.png] Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data.

[PMID 19207020OA-icon.png] Meta-analysis in genome-wide association studies.

[PMID 19323962OA-icon.png] Genome-wide association studies in type 2 diabetes.

[PMID 19526209OA-icon.png] Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants?

[PMID 19602701OA-icon.png] Underlying genetic models of inheritance in established type 2 diabetes associations.

[PMID 19741467] Association of common type 2 diabetes risk gene variants and posttransplantation diabetes mellitus in renal allograft recipients in Korea.

[PMID 19931040OA-icon.png] Simultaneous genotype calling and haplotype phasing improves genotype accuracy and reduces false-positive associations for genome-wide association studies.

[PMID 20017978OA-icon.png] Influence of control selection in genome-wide association studies: the example of diabetes in the Framingham Heart Study.

[PMID 20018041OA-icon.png] The effect of multiple genetic variants in predicting the risk of type 2 diabetes.

[PMID 20126254OA-icon.png] Rare variants create synthetic genome-wide associations.

[PMID 20144327OA-icon.png] A genomics study of type 2 diabetes mellitus in U.S. Air Force personnel.

[PMID 20509872OA-icon.png] Implication of genetic variants near SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2, KCNQ1, and WFS1 in type 2 diabetes in a Chinese population.

[PMID 20532014OA-icon.png] The epidemiology of diabetes in Korea: from the economics to genetics.

[PMID 20550665OA-icon.png] Association study of genetic variants in eight genes/loci with type 2 diabetes in a Han Chinese population.

[PMID 21368910OA-icon.png] Heterogeneity of genetic associations of CDKAL1 and HHEX with susceptibility of type 2 diabetes mellitus by gender.

[PMID 22377712] Association between type 2 diabetes genetic susceptibility loci and visceral and subcutaneous fat area as determined by computed tomography.

GWAS snp
PMID [PMID 22693455OA-icon.png]
Title Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases.
Risk Allele C
P-val 2E-9
Odds Ratio 1.1800 None

GET Evidence
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.382812

[PMID 24112421OA-icon.png] CDKAL1 and HHEX are associated with type-2 diabetes-related traits among Yup'ik people

[PMID 24371822OA-icon.png] IRS1, TCF7L2, ADRB1, PPARG, and HHEX Polymorphisms Associated with Atherogenic Risk in Mexican Population

[PMID 23298195] Association study of genetic variants of 17 diabetes-related genes/loci and cardiovascular risk and diabetic nephropathy in the Chinese She population.

[PMID 23462794OA-icon.png] Identification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets.