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rs5031017

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(G;G) 0 normal
(G;T) 1.5 One copy of CYP2A6*5 non-functioning variant; impaired nicotine metabolism
(T;T) 2 Two copies of CYP2A6*5 non-functioning variant; impaired nicotine metabolism
ReferenceGRCh38 38.1/141
Chromosome19
Position40843845
GeneCYP2A6
is asnp
is mentioned by
dbSNPrs5031017
ebirs5031017
HLIrs5031017
Exacrs5031017
Varsomers5031017
Maprs5031017
PheGenIrs5031017
hapmaprs5031017
1000 genomesrs5031017
hgdprs5031017
ensemblrs5031017
gopubmedrs5031017
geneviewrs5031017
scholarrs5031017
googlers5031017
pharmgkbrs5031017
gwascentralrs5031017
openSNPrs5031017
23andMers5031017
23andMe allrs5031017
SNP Nexus

SNPshotrs5031017
SNPdbers5031017
MSV3drs5031017
GWAS Ctlgrs5031017
Max Magnitude2
? (G;G) (G;T) (T;T) 28
rs5031017 in the CYP2A6 gene, also known as G479V, 1436G>T or 6582G>T, the T allele indicates the CYP2A6*5 inactive form of the gene.

[PMID 21205058OA-icon.png] reports that poor metabolizers (such as those with inactive forms of CYP2A6), among male smokers and compared to normal smokers, smoked fewer cigarettes, took longer to smoke regularly, and if they had stopped smoking, waited a shorter period of time before making the decision. Unfortunately, this group also had a lower likelihood of smoking cessation.

Smoking