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rs507666

From SNPedia

Orientationplus
Stabilizedplus
Make rs507666(A;A)
Make rs507666(A;G)
Make rs507666(G;G)
ReferenceGRCh38 38.1/141
Chromosome9
Position133273983
GeneABO
is asnp
is mentioned by
dbSNPrs507666
ebirs507666
HLIrs507666
Exacrs507666
Varsomers507666
Maprs507666
PheGenIrs507666
hapmaprs507666
1000 genomesrs507666
hgdprs507666
ensemblrs507666
gopubmedrs507666
geneviewrs507666
scholarrs507666
googlers507666
pharmgkbrs507666
gwascentralrs507666
openSNPrs507666
23andMers507666
23andMe allrs507666
SNP Nexus

SNPshotrs507666
SNPdbers507666
MSV3drs507666
GWAS Ctlgrs507666
GMAF0.1644
Max Magnitude
GWAS
SNP rs507666
PubMedID [PMID 18604267OA-icon.png]
Condition Soluble ICAM-1
Gene ABO
Risk Allele G
pValue 5.00E-029
OR 17.73
95% CI NR) umol/L decreas



GWAS snp
PMID [PMID 21533024OA-icon.png]
Trait
Title Genome-wide association analysis of soluble ICAM-1 concentration reveals novel associations at the NFKBIK, PNPLA3, RELA, and SH2B3 loci.
Risk Allele A
P-val 3E-91
Odds Ratio 17.3000 [NR] ng/mL decrease
ABO blood group


[PMID 19474294OA-icon.png] Potential etiologic and functional implications of genome-wide association loci for human diseases and traits.


[PMID 19648918OA-icon.png] Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer.

rs507666, at the ABO (9q34.2) locus is highly correlated with sICAM-1 concentrations. The novel association at the ABO locus provides evidence for a previously unknown regulatory role of histo-blood group antigens in inflammatory adhesion processes.[18604267?dopt=Abstract PMID 18604267OA-icon.png]


GET Evidence
rs507666
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.132812
summary



GWAS snp
PMID [PMID 24386095OA-icon.png]
Trait Lipid traits
Title A genome wide association study identifies common variants associated with lipid levels in the Chinese population.
Risk Allele A
P-val 4E-11
Odds Ratio .02 [0.0091-0.0209] mmol/L increase