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rs5092

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(A;A) more likely to gain weight if taking olanzapine
(A;G) less likely to gain weight if taking olanzapine
(G;G) less likely to gain weight if taking olanzapine
ReferenceGRCh38 38.1/141
Chromosome11
Position116822748
GeneAPOA4
is asnp
is mentioned by
dbSNPrs5092
ebirs5092
HLIrs5092
Exacrs5092
Varsomers5092
Maprs5092
PheGenIrs5092
hapmaprs5092
1000 genomesrs5092
hgdprs5092
ensemblrs5092
gopubmedrs5092
geneviewrs5092
scholarrs5092
googlers5092
pharmgkbrs5092
gwascentralrs5092
openSNPrs5092
23andMers5092
23andMe allrs5092
SNP Nexus

SNPshotrs5092
SNPdbers5092
MSV3drs5092
GWAS Ctlgrs5092
GMAF0.2507
Max Magnitude
rs5092 is a SNP in the apolipoprotein A4 APOA4 gene.

In a study of 67 mostly Caucasian patients prescribed the atypical antipsychotic olanzapine, carriers of a rs5092(G) allele were less likely to gain significant weight compared to rs5092(A;A) carriers, as assessed by physiogenomic analysis of corresponding weight profiles. Two other SNPs, rs4765623 and rs7412, were also significantly associated with weight profiles in these patients.[PMID 17199131]


[PMID 19592705OA-icon.png] Effects of variations in the APOA1/C3/A4/A5 gene cluster on different parameters of postprandial lipid metabolism in healthy young men


[PMID 18254975OA-icon.png] Physiogenomic comparison of human fat loss in response to diets restrictive of carbohydrate or fat.


[PMID 19057464OA-icon.png] Pharmacogenetic association of the APOA1/C3/A4/A5 gene cluster and lipid responses to fenofibrate: the genetics of lipid-lowering drugs and diet network study.