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rs518147

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(C;C) less weight gain if taking olanzapine
(C;G) normal
(G;G) normal
ReferenceGRCh38 38.1/141
ChromosomeX
Position114584109
GeneHTR2C
is asnp
is mentioned by
dbSNPrs518147
ebirs518147
HLIrs518147
Exacrs518147
Varsomers518147
Maprs518147
PheGenIrs518147
hapmaprs518147
1000 genomesrs518147
hgdprs518147
ensemblrs518147
gopubmedrs518147
geneviewrs518147
scholarrs518147
googlers518147
pharmgkbrs518147
gwascentralrs518147
openSNPrs518147
23andMers518147
23andMe allrs518147
SNP Nexus

SNPshotrs518147
SNPdbers518147
MSV3drs518147
GWAS Ctlgrs518147
GMAF0.2926
Max Magnitude
? (C;C) (C;G) (G;G) 28
rs518147, also known as -697G/C, is a SNP in the 5-hydroxytryptamine (serotonin) receptor 2C HTR2C gene.

A study of 107 patients with schizophrenia being treated with olanzapine reported a protective effect against weight-gain from the (C) allele of this SNP; fewer patients (of 28) with a rs518147(C) allele had a body mass index increase of >=10% (p=0.0006), whereas (G;G) homozygotes did. This effect may also involve nearby SNP rs3813929.[PMID 19434072]


[PMID 19416518OA-icon.png] Investigation of the serotonin 2C receptor gene in attention deficit hyperactivity disorder in UK samples


[PMID 17016522] The association between HTR2C polymorphisms and obesity in psychiatric patients using antipsychotics: a cross-sectional study.

[PMID 17632216] The association between HTR2C gene polymorphisms and the metabolic syndrome in patients with schizophrenia.

[PMID 18081710OA-icon.png] Multivariate permutation analysis associates multiple polymorphisms with subphenotypes of major depression.

[PMID 19142101] HTR2C gene polymorphisms and the metabolic syndrome in patients with schizophrenia: a replication study.

[PMID 20060656] Association of polymorphisms of the serotonergic system with smoking initiation in Caucasians.

[PMID 20415561] HTR2C promoter polymorphisms are associated with risperidone efficacy in Chinese female patients.

[PMID 21391883] Functional consequences of two HTR2C polymorphisms associated with antipsychotic-induced weight gain.


GET Evidence
rs518147
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.360465
summary



[PMID 22914617] Analysis of the BTBD9 and HTR2C variants in Chinese Han patients with Tourette syndrome.