|(C;C)||less weight gain if taking olanzapine|
A study of 107 patients with schizophrenia being treated with olanzapine reported a protective effect against weight-gain from the (C) allele of this SNP; fewer patients (of 28) with a rs518147(C) allele had a body mass index increase of >=10% (p=0.0006), whereas (G;G) homozygotes did. This effect may also involve nearby SNP rs3813929.[PMID 19434072]
[PMID 19416518] Investigation of the serotonin 2C receptor gene in attention deficit hyperactivity disorder in UK samples
[PMID 17016522] The association between HTR2C polymorphisms and obesity in psychiatric patients using antipsychotics: a cross-sectional study.
[PMID 17632216] The association between HTR2C gene polymorphisms and the metabolic syndrome in patients with schizophrenia.
[PMID 18081710] Multivariate permutation analysis associates multiple polymorphisms with subphenotypes of major depression.
[PMID 19142101] HTR2C gene polymorphisms and the metabolic syndrome in patients with schizophrenia: a replication study.
[PMID 20060656] Association of polymorphisms of the serotonergic system with smoking initiation in Caucasians.
[PMID 20415561] HTR2C promoter polymorphisms are associated with risperidone efficacy in Chinese female patients.
[PMID 21391883] Functional consequences of two HTR2C polymorphisms associated with antipsychotic-induced weight gain.
|qualified_impact||Insufficiently evaluated pharmacogenetic|
[PMID 22914617] Analysis of the BTBD9 and HTR2C variants in Chinese Han patients with Tourette syndrome.