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rs5277

From SNPedia

Orientationminus
Stabilizedminus
Make rs5277(C;C)
Make rs5277(C;G)
Make rs5277(G;G)
ReferenceGRCh38 38.1/141
Chromosome1
Position186679065
GenePTGS2
is asnp
is mentioned by
dbSNPrs5277
ebirs5277
HLIrs5277
Exacrs5277
Varsomers5277
Maprs5277
PheGenIrs5277
hapmaprs5277
1000 genomesrs5277
hgdprs5277
ensemblrs5277
gopubmedrs5277
geneviewrs5277
scholarrs5277
googlers5277
pharmgkbrs5277
gwascentralrs5277
openSNPrs5277
23andMers5277
23andMe allrs5277
SNP Nexus

SNPshotrs5277
SNPdbers5277
MSV3drs5277
GWAS Ctlgrs5277
GMAF0.09458
Max Magnitude
? (C;C) (C;G) (G;G) 28
rs5277 is a SNP in the prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) PTGS2 gene, also known as COX-2.

A meta-analysis involving nine studies with 6,968 breast cancer cases and 9,126 controls found just a borderline significant increased risk (of breast cancer) in a recessive model (odds ratio 1.217, CI: 0.958-1.547, p = 0.107).[PMID 20033767]


[PMID 19820421] The Effect of Genetic Polymorphisms of Cyclooxygenase 2 on Acute Pancreatitis in Turkey


[PMID 19755647OA-icon.png] Cyclooxygenase-2 polymorphisms, aspirin treatment, and risk for colorectal adenoma recurrence--data from a randomized clinical trial


[PMID 20711808OA-icon.png] Polymorphisms in oxidative stress and inflammation pathway genes, low-dose ionizing radiation, and the risk of breast cancer among US radiologic technologists


[PMID 21705955] Cyclooxygenase-2 polymorphisms and pancreatic cancer susceptibility

[PMID 17171651] Cyclooxygenase-2 polymorphisms in Parkinson's disease.

[PMID 17214885OA-icon.png] A polymorphism in the 3' untranslated region of the gene encoding prostaglandin endoperoxide synthase 2 is not associated with an increase in breast cancer risk: a nested case-control study.

[PMID 17404026] Lack of association of the cyclooxygenase-2 and inducible nitric oxide synthase gene polymorphism with risk of cervical cancer in Korean population.

[PMID 17999989] Polymorphic variants in PTGS2 and prostate cancer risk: results from two large nested case-control studies.

[PMID 18085997] Pyrosequencing of polymorphisms in the COX-2 gene (PTGS2) with reported clinical relevance.

[PMID 18768181OA-icon.png] Association of polymorphisms in cyclooxygenase (COX)-2 with coronary and carotid calcium in the Diabetes Heart Study.

[PMID 18992148OA-icon.png] Low-penetrance alleles predisposing to sporadic colorectal cancers: a French case-controlled genetic association study.

[PMID 19223558OA-icon.png] Polymorphic variation in NFKB1 and other aspirin-related genes and risk of Hodgkin lymphoma.

[PMID 19318492OA-icon.png] Dietary omega-3 fatty acids, cyclooxygenase-2 genetic variation, and aggressive prostate cancer risk.

[PMID 19437564OA-icon.png] No association between cyclooxygenase-2 and uridine diphosphate glucuronosyltransferase 1A6 genetic polymorphisms and colon cancer risk.

[PMID 19661089OA-icon.png] Genetic variation in immune regulation and DNA repair pathways and stomach cancer in China.


[PMID 22464751OA-icon.png] SNPs in PTGS2 and LTA predict pain and quality of life in long term lung cancer survivors.


[PMID 23029430OA-icon.png] Prognostic role of host cyclooxygenase and cytokine genotypes in a Caucasian cohort of patients with gastric adenocarcinoma.


[PMID 24870748] The Prostaglandin Synthase 2/cyclooxygenase 2 (PTGS2/ COX2) rs5277 Polymorphism Does not Influence Risk of Colorectal Cancer in an Iranian Population


[PMID 26081267] Genetic Variants in Cyclooxygenase-2 Contribute to Post-treatment Pain among Endodontic Patients