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rs5361

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(A;A) 0 normal risk
(A;C) normal risk
(C;C) 2.5 4x increased risk for recurrent venous thromboembolism.
ReferenceGRCh38 38.1/142
Chromosome1
Position169731919
GeneSELE
is asnp
is mentioned by
dbSNPrs5361
ebirs5361
HLIrs5361
Exacrs5361
Varsomers5361
Maprs5361
PheGenIrs5361
hapmaprs5361
1000 genomesrs5361
hgdprs5361
ensemblrs5361
gopubmedrs5361
geneviewrs5361
scholarrs5361
googlers5361
pharmgkbrs5361
gwascentralrs5361
openSNPrs5361
23andMers5361
23andMe allrs5361
SNP Nexus

SNPshotrs5361
SNPdbers5361
MSV3drs5361
GWAS Ctlgrs5361
GMAF0.0551
Max Magnitude2.5
? (A;A) (A;C) (C;C) 28
The rs5361 Ser128Arg variation in this gene, known as E-selectin, is linked to several thrombotic disorders.

rs5361(C;C) homozygous carriers of the Ser128Arg allele are at a 4X higher risk for recurrent venous thromboembolism (VTE); heterozygous carriers are not at increased risk. [PMID 16908800].


[PMID 22589243] Association of E-selectin gene polymorphisms with ischemic stroke in a Chinese Han population


[PMID 15726497OA-icon.png] Gene-environment interaction effects on the development of immune responses in the 1st year of life.


[PMID 16820586OA-icon.png] Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery.


[PMID 17327408OA-icon.png] Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival.


[PMID 18513389OA-icon.png] New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background.


[PMID 18633131OA-icon.png] Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era.


[PMID 19066394OA-icon.png] Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma.


[PMID 19131662OA-icon.png] A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.


[PMID 19263529OA-icon.png] Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach.


[PMID 19330901OA-icon.png] Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study.


[PMID 19559392OA-icon.png] A candidate gene association study of 77 polymorphisms in migraine.


[PMID 20622166OA-icon.png] Combined effect of inflammatory gene polymorphisms and the risk of ischemic stroke in a prospective cohort of subjects with type 2 diabetes: a Go-DARTS study.


[PMID 22116284] A two-step genetic study on quantitative precursors of coronary artery disease in a homogeneous Indian population: case-control association discovery and validation by transmission-disequilibrium test.


[PMID 22388798OA-icon.png] Gene panels to help identify subgroups at high and low risk of coronary heart disease among those randomized to antihypertensive treatment: the GenHAT study.


[PMID 22414298] Lack of an association between E-selectin gene polymorphisms and risk of Kawasaki disease.


GET Evidence
SELE-S149R
aa_change Ser149Arg
aa_change_short S149R
impact not reviewed
qualified_impact Insufficiently evaluated not reviewed
overall_frequency 0.0835657
summary



[PMID 21780194] E-selectin rs5361 and FCGR2A rs1801274 variants were associated with increased risk of gastric cancer in a Chinese population.


[PMID 23274712OA-icon.png] Genetic polymorphisms and the risk of myocardial infarction in patients under 45 years of age.


[PMID 23533563OA-icon.png] Novel risk factors for premature peripheral arterial occlusive disease in non-diabetic patients: a case-control study.


[PMID 23772946] Association of cell adhesion molecule gene polymorphisms with recurrent aphthous stomatitis.


[PMID 25091233] Association of F11 polymorphism rs2289252 with deep vein thrombosis and related phenotypes in population of Latvia