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rs540825

From SNPedia

Orientationminus
Stabilizedminus
Make rs540825(A;A)
Make rs540825(A;T)
Make rs540825(T;T)
ReferenceGRCh38 38.1/141
Chromosome6
Position154093311
GeneOPRM1
is asnp
is mentioned by
dbSNPrs540825
ebirs540825
HLIrs540825
Exacrs540825
Varsomers540825
Maprs540825
PheGenIrs540825
hapmaprs540825
1000 genomesrs540825
hgdprs540825
ensemblrs540825
gopubmedrs540825
geneviewrs540825
scholarrs540825
googlers540825
pharmgkbrs540825
gwascentralrs540825
openSNPrs540825
23andMers540825
23andMe allrs540825
SNP Nexus

SNPshotrs540825
SNPdbers540825
MSV3drs540825
GWAS Ctlgrs540825
GMAF0.1263
Max Magnitude
? (A;A) (A;T) (T;T) 28

Psychiatric Times This SNP is located in an alternatively spliced exon of the OPRM1 gene and is found only in the MOR1X isoform. Preliminary data suggest that when expressed in cultured cells, this isoform differs significantly from the typical MOR1 isoform in its regulation by membrane trafficking (M. Tanowitz, M. von Zastrow, personal oral communication, 2008).


[PMID 15558714] Novel exonic mu-opioid receptor gene (OPRM1) polymorphisms not associated with opioid dependence.


[PMID 19053977OA-icon.png] OPRM1 Asn40Asp predicts response to naltrexone treatment: a haplotype-based approach.


[PMID 19103668OA-icon.png] Expansion of the human mu-opioid receptor gene architecture: novel functional variants.


[PMID 20194481OA-icon.png] Association of mu-opioid receptor variants and response to citalopram treatment in major depressive disorder.


GET Evidence
OPRM1-Q402H
aa_change Gln402His
aa_change_short Q402H
impact not reviewed
qualified_impact Insufficiently evaluated not reviewed
overall_frequency 0.820189
summary



[PMID 23144877OA-icon.png] A Non-Synonymous Single Nucleotide Polymorphism in an OPRM1 Splice Variant Is Associated with Fentanyl-Induced Emesis in Women Undergoing Minor Gynaecological Surgery