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rs543749

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(G;G) 2.1 if a smoker, higher risk risk for COPD in somkers in a Hispanic population
Make rs543749(G;T)
Make rs543749(T;T)
ReferenceGRCh38 38.1/141
Chromosome20
Position3669032
GeneADAM33
is asnp
is mentioned by
dbSNPrs543749
ebirs543749
HLIrs543749
Exacrs543749
Varsomers543749
Maprs543749
PheGenIrs543749
hapmaprs543749
1000 genomesrs543749
hgdprs543749
ensemblrs543749
gopubmedrs543749
geneviewrs543749
scholarrs543749
googlers543749
pharmgkbrs543749
gwascentralrs543749
openSNPrs543749
23andMers543749
23andMe allrs543749
SNP Nexus

SNPshotrs543749
SNPdbers543749
MSV3drs543749
GWAS Ctlgrs543749
GMAF0.1749
Max Magnitude2.1
rs543749, also known as IVS21_22 or V-1, is a SNP in the ADAM metallopeptidase domain 33 ADAM33 gene.

A study of ~600 non-Hispanic white males who smoked concluded that rs543749(G;G) carriers, i.e. those homozygous for the most common allele, were more likely (p< 0.0026, after Bonferroni correction) to develop chronic obstructive pulmonary disease (COPD) than carriers of one or two rs543749(T) alleles.10.1186/1465-9921-10-21[PMID 17878941OA-icon.png] ADAM33, a new candidate for psoriasis susceptibility.


[PMID 18560587OA-icon.png] Replication of association between ADAM33 polymorphisms and psoriasis.


[PMID 19284602OA-icon.png] Adam33 polymorphisms are associated with COPD and lung function in long-term tobacco smokers.


[PMID 21320344OA-icon.png] Evaluation of genetic susceptibility to childhood allergy and asthma in an African American urban population.


[PMID 23380143] A disintegrin and metalloprotease 33 (ADAM33) gene polymorphisms and the risk of asthma: a meta-analysis.