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rs5491

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 0 common in complete genomics
Make rs5491(A;T)
Make rs5491(T;T)
ReferenceGRCh38 38.1/141
Chromosome19
Position10274864
GeneICAM1
is asnp
is mentioned by
dbSNPrs5491
ebirs5491
HLIrs5491
Exacrs5491
Varsomers5491
Maprs5491
PheGenIrs5491
hapmaprs5491
1000 genomesrs5491
hgdprs5491
ensemblrs5491
gopubmedrs5491
geneviewrs5491
scholarrs5491
googlers5491
pharmgkbrs5491
gwascentralrs5491
openSNPrs5491
23andMers5491
23andMe allrs5491
SNP Nexus

SNPshotrs5491
SNPdbers5491
MSV3drs5491
GWAS Ctlgrs5491
GMAF0.07484
Max Magnitude0
? (A;A) (A;T) (T;T) 28
[PMID 19332210OA-icon.png] Candidate genetic variants in the fibrinogen, methylenetetrahydrofolate reductase, and intercellular adhesion molecule-1 genes and plasma levels of fibrinogen, homocysteine, and intercellular adhesion molecule-1 among various race/ethnic groups: Data from the Women's Genome Health Study


[PMID 18420209OA-icon.png] ICAM1 and VCAM1 polymorphisms, coronary artery calcium, and circulating levels of soluble ICAM-1: the multi-ethnic study of atherosclerosis (MESA)

OMIM147840
Desc
Variant0001
Relatedalso
[PMID 21392767OA-icon.png] Polymorphisms in the ICAM1 gene predict circulating soluble intercellular adhesion molecule-1(sICAM-1)


ClinVar
Risk rs5491(G,T;G,T)
Alt rs5491(G,T;G,T)
Reference rs5491(A;A)
Significance Other
Disease Malaria
Variation info
Gene ICAM1
CLNDBN Malaria, cerebral, susceptibility to
Reversed 0
HGVS NC_000019.9:g.10385540A>T
CLNSRC OMIM Allelic Variant
CLNACC RCV000015768.3,



[PMID 15726497OA-icon.png] Gene-environment interaction effects on the development of immune responses in the 1st year of life.


[PMID 16625213] ICAM1 amino-acid variant K469E is associated with paediatric bronchial asthma and elevated sICAM1 levels.


[PMID 16642433OA-icon.png] Polymorphism in maternal LRP8 gene is associated with fetal growth.


[PMID 17327408OA-icon.png] Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival.


[PMID 17668374OA-icon.png] Combining evidence of natural selection with association analysis increases power to detect malaria-resistance variants.


[PMID 17903293OA-icon.png] Genome-wide association with select biomarker traits in the Framingham Heart Study.


[PMID 18045607OA-icon.png] Circulating soluble ICAM-1 levels shows linkage to ICAM gene cluster region on chromosome 19: the NHLBI Family Heart Study follow-up examination.


[PMID 18528404OA-icon.png] Variation in the ICAM1 gene is not associated with severe malaria phenotypes.


[PMID 18604267OA-icon.png] Novel association of ABO histo-blood group antigen with soluble ICAM-1: results of a genome-wide association study of 6,578 women.


[PMID 18633131OA-icon.png] Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era.


[PMID 19055786OA-icon.png] Variations in host genes encoding adhesion molecules and susceptibility to falciparum malaria in India.


[PMID 19066394OA-icon.png] Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma.


[PMID 19131662OA-icon.png] A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.


[PMID 19330901OA-icon.png] Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study.


[PMID 19559392OA-icon.png] A candidate gene association study of 77 polymorphisms in migraine.


[PMID 20031567OA-icon.png] An evaluation of candidate genes of inflammation and thrombosis in relation to the risk of venous thromboembolism: The Women's Genome Health Study.


[PMID 20494378] Association between functional variants of the ICAM1 and CRP genes and metabolic syndrome in Taiwanese subjects.


GET Evidence
ICAM1-K56M
aa_change Lys56Met
aa_change_short K56M
impact not reviewed
qualified_impact Insufficiently evaluated not reviewed
overall_frequency 0.0746421
summary



[PMID 23114149] [Effects of ICAM-1 Gene K469E, K56M Polymorphisms on Plasma sICAM-1 Expression Levels in Chinese Yugur, Tibetan and Han Nationalities]


[PMID 24069166OA-icon.png] Combined effects of icam-1 single-nucleotide polymorphisms and environmental carcinogens on oral cancer susceptibility and clinicopathologic development


[PMID 24955718] Interaction of Intercellular Adhesion Molecule 1 (ICAM1) Polymorphisms and Environmental Tobacco Smoke on Childhood Asthma


[PMID 25003170OA-icon.png] Interaction of intercellular adhesion molecule 1 (ICAM1) polymorphisms and environmental tobacco smoke on childhood asthma


[PMID 26078712OA-icon.png] Impact of Intercellular Adhesion Molecule-1 Genetic Polymorphisms on Coronary Artery Disease Susceptibility in Taiwanese Subjects


[PMID 26341495] Association of intercellular adhesion molecule-1 single nucleotide polymorphisms with hepatocellular carcinoma susceptibility and clinicopathologic development


[PMID 26377999] Single-Nucleotide Polymorphisms and Haplotypes of Intercellular Adhesion Molecule-1 in Uterine Cervical Carcinogenesis in Taiwanese Women