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rs560887

From SNPedia

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Stabilizedminus
Geno Mag Summary
(A;A) 2 Avg. fasting Plasma Glucose 5.06 mmol/L (91 mg/dl).
(A;G) 2 Avg. fasting Plasma Glucose 5.12 mmol/L (92 mg/dl).
(G;G) 2.1 Avg. fasting Plasma Glucose 5.18 mmol/L (93 mg/dl).
ReferenceGRCh37 37.1/131
Chromosome2
Position169763148
GeneG6PC2
is asnp
is mentioned by
dbSNPrs560887
ebirs560887
HLIrs560887
Exacrs560887
Varsomers560887
Maprs560887
PheGenIrs560887
hapmaprs560887
1000 genomesrs560887
hgdprs560887
ensemblrs560887
gopubmedrs560887
geneviewrs560887
scholarrs560887
googlers560887
pharmgkbrs560887
gwascentralrs560887
openSNPrs560887
23andMers560887
23andMe allrs560887
SNP Nexus

SNPshotrs560887
SNPdbers560887
MSV3drs560887
GWAS Ctlgrs560887
GMAF0.1515
Max Magnitude2.1
? (A;A) (A;G) (G;G) 28

[PMID 18451265] rs560887, p = 4 x 10(-7))

  • 654 normoglycemic subjects, replicated in 9,353 subjects
  • fasting plasma glucose (FPG) (beta = -0.06 mmol/l per A-allele, combined p = 4 x 10(-23)) and with pancreatic beta-cell function (Homa-B model, combined p = 3 x 10(-13)) in three populations; however it was not associated with type 2 diabetes risk.
GWAS
SNP rs560887
PubMedID [PMID 18451265]
Condition Fasting plasma glucose
Gene G6PC2
Risk Allele A
pValue 4.00E-023
OR 0.06
95% CI 0.05-0.08) mmol/l decreas


GWAS snp
PMID [PMID 19060910OA-icon.png]
Trait Other metabolic traits
Title Genome-wide association analysis of metabolic traits in a birth cohort from a founder population
Risk Allele A
P-val 6E-10
Odds Ratio 0.06 [0.04-0.07] mmol/l decrease
GWAS snp
PMID [PMID 19060907OA-icon.png]
Trait Fasting plasma glucose
Title Variants in MTNR1B influence fasting glucose levels
Risk Allele C
P-val 1E-57
Odds Ratio 0.06 [0.05-0.07] mmol/l increase
OMIM612108
DescFASTING PLASMA GLUCOSE LEVEL QUANTITATIVE TRAIT LOCUS 1; FGQTL1
Variant
Relatedalso
[PMID 19651812OA-icon.png] Common genetic variation near melatonin receptor MTNR1B contributes to raised plasma glucose and increased risk of type-2 diabetes amongst Indian Asians and European whites

[PMID 19741166OA-icon.png] Common Genetic Determinants of Glucose Homeostasis in Healthy Children: The European Youth Heart Study (EYHS)


[PMID 20029179OA-icon.png] Association of a Common G6PC2 Variant with Fasting Plasma Glucose Levels in Non-Diabetic Individuals

GWAS snp
PMID [PMID 20081858OA-icon.png]
Trait Fasting glucose-related traits
Title New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
Risk Allele C
P-val 2E-66
Odds Ratio None None


[PMID 20826583] The Impact of Genetic Variation in the G6PC2 Gene on Insulin Secretion Depends on Glycemia

[PMID 20839289OA-icon.png] Impact of repeated measures and sample selection on genome-wide association studies of fasting glucose





[PMID 21036910OA-icon.png] Association of a fasting glucose genetic risk score with subclinical atherosclerosis: The Atherosclerosis Risk in Communities (ARIC) Study

GWAS snp
PMID [PMID 22508271OA-icon.png]
Trait
Title Fasting glucose GWAS candidate region analysis across ethnic groups in the Multiethnic Study of Atherosclerosis (MESA).
Risk Allele T
P-val 0.000002
Odds Ratio 1.2900 None
GWAS snp
PMID [PMID 22399527OA-icon.png]
Trait
Title Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits.
Risk Allele G
P-val 5E-26
Odds Ratio 0.1500 None
GWAS snp
PMID [PMID 22286219OA-icon.png]
Trait
Title Genome-wide association study identifies multiple loci influencing human serum metabolite levels.
Risk Allele
P-val 2E-17
Odds Ratio 0.1500 None


[PMID 18521185OA-icon.png] Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels.


[PMID 18984742OA-icon.png] A single-nucleotide polymorphism in a methylatable Foxa2 binding site of the G6PC2 promoter is associated with insulin secretion in vivo and increased promoter activity in vitro.


[PMID 19096518OA-icon.png] Novel association of HK1 with glycated hemoglobin in a non-diabetic population: a genome-wide evaluation of 14,618 participants in the Women's Genome Health Study.


[PMID 19533084OA-icon.png] Combined effects of single-nucleotide polymorphisms in GCK, GCKR, G6PC2 and MTNR1B on fasting plasma glucose and type 2 diabetes risk.


[PMID 19669124] A variant in the G6PC2/ABCB11 locus is associated with increased fasting plasma glucose, increased basal hepatic glucose production and increased insulin release after oral and intravenous glucose loads.


[PMID 19741163OA-icon.png] Additive effects of genetic variation in GCK and G6PC2 on insulin secretion and fasting glucose.


[PMID 19937311] Common variants at the GCK, GCKR, G6PC2-ABCB11 and MTNR1B loci are associated with fasting glucose in two Asian populations.


[PMID 20043853OA-icon.png] Prioritizing genes for follow-up from genome wide association studies using information on gene expression in tissues relevant for type 2 diabetes mellitus.


[PMID 20622168OA-icon.png] Genetic and functional assessment of the role of the rs13431652-A and rs573225-A alleles in the G6PC2 promoter that are strongly associated with elevated fasting glucose levels.


[PMID 20628598OA-icon.png] Common polymorphisms in MTNR1B, G6PC2 and GCK are associated with increased fasting plasma glucose and impaired beta-cell function in Chinese subjects.


[PMID 20870969OA-icon.png] Genetic predisposition to long-term nondiabetic deteriorations in glucose homeostasis: Ten-year follow-up of the GLACIER study. (ageing)

GWAS snp
PMID [PMID 22581228OA-icon.png]
Trait
Title A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
Risk Allele
P-val 2E-113
Odds Ratio None None


GET Evidence
rs560887
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.793084
summary



Blood Glucose


[PMID 23508304OA-icon.png] Multiple functional polymorphisms in the G6PC2 gene contribute to the association with higher fasting plasma glucose levels

GWAS snp
PMID [PMID 22916037OA-icon.png]
Trait Metabolite levels
Title Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.
Risk Allele
P-val 4E-15
Odds Ratio NR NR


[PMID 23840762OA-icon.png] Large Scale Meta-Analyses of Fasting Plasma Glucose Raising Variants in GCK, GCKR, MTNR1B and G6PC2 and Their Impacts on Type 2 Diabetes Mellitus Risk


[PMID 22438186] A SNP in G6PC2 predicts insulin secretion in type 1 diabetes

GWAS snp
PMID [PMID 23903356OA-icon.png]
Trait Glycemic traits (pregnancy)
Title Identification of HKDC1 and BACE2 as genes influencing glycemic traits during pregnancy through genome-wide association studies.
Risk Allele T
P-val 2E-16
Odds Ratio .01 [NR] unit decrease


[PMID 22486180] HbA1c-based diabetes diagnosis among patients with glucokinase mutation (GCK-MODY) is affected by a genetic variant of glucose-6-phosphatase (G6PC2).


[PMID 22698489OA-icon.png] Nonfasting glucose, ischemic heart disease, and myocardial infarction: a Mendelian randomization study.

GWAS snp
PMID [PMID 24405752OA-icon.png]
Trait Glycated hemoglobin levels
Title Genome-wide association study identifies common loci influencing circulating glycated hemoglobin (HbA1c) levels in non-diabetic subjects: the Long Life Family Study (LLFS).
Risk Allele T
P-val 1E-17
Odds Ratio .03 [0.024-0.040] unit decrease