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rs569108

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(A;A) 0
(C;C)  ?
(C;T) 3x risk of predisposition to childhood asthma in a Japanese population
(T;T) 0 normal
ReferenceGRCh38 38.1/141
Chromosome11
Position60095631
GeneMS4A2
is asnp
is mentioned by
dbSNPrs569108
ebirs569108
HLIrs569108
Exacrs569108
Varsomers569108
Maprs569108
PheGenIrs569108
hapmaprs569108
1000 genomesrs569108
hgdprs569108
ensemblrs569108
gopubmedrs569108
geneviewrs569108
scholarrs569108
googlers569108
pharmgkbrs569108
gwascentralrs569108
openSNPrs569108
23andMers569108
23andMe allrs569108
SNP Nexus

SNPshotrs569108
SNPdbers569108
MSV3drs569108
GWAS Ctlgrs569108
GMAF0.1194
Max Magnitude0
? (C;C) (C;T) (T;T) 28
rs569108, a SNP in the MS4A2 gene, has been linked in a Japanese population to a predisposition to childhood asthma, with an odds ratio of 3 [PMID 8842731, PMID 8968765]. The risk allele in dbSNP orientation is (C). [Note: no (C;C) homozygotes were observed in this population.]
OMIM147138
Desc
Variant0001
Relatedalso


ClinVar
Risk rs569108(C;C)
Alt rs569108(C;C)
Reference rs569108(T;T)
Significance Other
Disease Atopic asthma
Variation info
Gene MS4A2
CLNDBN Atopic asthma, susceptibility to
Reversed 1
HGVS NC_000011.9:g.59863104A>G
CLNSRC OMIM Allelic Variant
CLNACC RCV000015930.3,



[PMID 15726497OA-icon.png] Gene-environment interaction effects on the development of immune responses in the 1st year of life.

[PMID 16519819OA-icon.png] Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases.

[PMID 19131662OA-icon.png] A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.

[PMID 19330901OA-icon.png] Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study.

[PMID 19559392OA-icon.png] A candidate gene association study of 77 polymorphisms in migraine.


GET Evidence
MS4A2-E237G
aa_change Glu237Gly
aa_change_short E237G
impact not reviewed
qualified_impact Insufficiently evaluated not reviewed
overall_frequency 0.0743633
summary



[PMID 27746735] FCERI and Histamine Metabolism Gene Variability in Selective Responders to NSAIDS.