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rs573225

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(C;C) 0 normal
(C;T) higher insulinogenic index in obese children
(T;T) higher insulinogenic index in obese children
ReferenceGRCh37 37.1/131
Chromosome2
Position169757541
GeneG6PC2
is asnp
is mentioned by
dbSNPrs573225
ebirs573225
HLIrs573225
Exacrs573225
Varsomers573225
Maprs573225
PheGenIrs573225
hapmaprs573225
1000 genomesrs573225
hgdprs573225
ensemblrs573225
gopubmedrs573225
geneviewrs573225
scholarrs573225
googlers573225
pharmgkbrs573225
gwascentralrs573225
openSNPrs573225
23andMers573225
23andMe allrs573225
SNP Nexus

SNPshotrs573225
SNPdbers573225
MSV3drs573225
GWAS Ctlgrs573225
GMAF0.1749
Max Magnitude0
? (C;C) (C;T) (T;T) 28
rs573225 is a SNP in the glucose-6-phosphatase, catalytic, 2 G6PC2 gene.

Based on a study of 734 young European children with obesity, the insulinogenic index (IGI) of insulin secretion was determined to be associated with rs573225 by linear regression analysis and was 30% greater in (T;T) or (C;T) genotypes than in (C;C) obese children (alleles oriented with respect to dbSNP). rs573225 was also associated with fasting glucose. [PMID 18984742OA-icon.png]


[PMID 19060907OA-icon.png] Variants in MTNR1B influence fasting glucose levels.


[PMID 20622168OA-icon.png] Genetic and functional assessment of the role of the rs13431652-A and rs573225-A alleles in the G6PC2 promoter that are strongly associated with elevated fasting glucose levels.


[PMID 23508304OA-icon.png] Multiple functional polymorphisms in the G6PC2 gene contribute to the association with higher fasting plasma glucose levels