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rs5743551

From SNPedia

Orientationminus
Stabilizedminus
Make rs5743551(A;A)
Make rs5743551(A;G)
Make rs5743551(G;G)
ReferenceGRCh38 38.1/141
Chromosome4
Position38806033
GeneTLR1
is asnp
is mentioned by
dbSNPrs5743551
ebirs5743551
HLIrs5743551
Exacrs5743551
Varsomers5743551
Maprs5743551
PheGenIrs5743551
hapmaprs5743551
1000 genomesrs5743551
hgdprs5743551
ensemblrs5743551
gopubmedrs5743551
geneviewrs5743551
scholarrs5743551
googlers5743551
pharmgkbrs5743551
gwascentralrs5743551
openSNPrs5743551
23andMers5743551
23andMe allrs5743551
SNP Nexus

SNPshotrs5743551
SNPdbers5743551
MSV3drs5743551
GWAS Ctlgrs5743551
GMAF0.4651
Max Magnitude
[PMID 18635889OA-icon.png] excessive inflammation during an infection and contribute to an increased risk for poor outcomes in patients with sepsis

G allele of TLR1-7202A/G (rs5743551)

associations with death, organ dysfunction

associated with elevated TLR1-mediated cytokine production (P < 2x10(-20))

predicted worse organ dysfunction and death (OR 1.82, 95% CI 1.07-3.09).

sepsis-related ALI (OR 3.40, 95% CI 1.59-7.27)

and gram-positive infection in sepsis.


[PMID 18396467OA-icon.png] Genetic variation and haplotype structures of innate immunity genes in eastern India.


[PMID 18752252] Genetic variation in the toll-like receptor gene cluster (TLR10-TLR1-TLR6) and prostate cancer risk.


[PMID 18768484OA-icon.png] Family-based samples can play an important role in genetic association studies.


[PMID 19505919OA-icon.png] Toll-like receptor signaling pathway variants and prostate cancer mortality.


[PMID 20200442OA-icon.png] Sequence variants in the TLR4 and TLR6-1-10 genes and prostate cancer risk. Results based on pooled analysis from three independent studies.


[PMID 21274447OA-icon.png] Genetic polymorphisms and posttraumatic complications.


[PMID 21872627] Association of polymorphisms in TLR genes and in genes of the Toll-like receptor signaling pathway with cancer risk.


[PMID 23478521OA-icon.png] Toll-Like Receptor 1 Polymorphisms and Associated Outcomes in Sepsis After Traumatic Injury: A Candidate Gene Association Study


[PMID 25128583] Association of TLR and TREM-1 Gene Polymorphisms with Risk of Coronary Artery Disease in a Russian Population


[PMID 25213166] An association between single nucleotide polymorphisms within TLR and TREM-1 genes and infective endocarditis