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rs5746059

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 0 slightly higher fat mass
(A;G) slightly higher fat mass
(G;G) 0 normal
ReferenceGRCh38 38.1/141
Chromosome1
Position12202735
GeneTNFRSF1B
is asnp
is mentioned by
dbSNPrs5746059
ebirs5746059
HLIrs5746059
Exacrs5746059
Varsomers5746059
Maprs5746059
PheGenIrs5746059
hapmaprs5746059
1000 genomesrs5746059
hgdprs5746059
ensemblrs5746059
gopubmedrs5746059
geneviewrs5746059
scholarrs5746059
googlers5746059
pharmgkbrs5746059
gwascentralrs5746059
openSNPrs5746059
23andMers5746059
23andMe allrs5746059
SNP Nexus

SNPshotrs5746059
SNPdbers5746059
MSV3drs5746059
GWAS Ctlgrs5746059
GMAF0.1506
Max Magnitude0
? (A;A) (A;G) (G;G) 28
rs5746059 is a SNP in the tumor necrosis factor-alpha receptor 2 TNFRSF1B gene.

A study of ~1,800 subjects from 400 Caucasian families concluded that carriers of a rs5746059(A) allele had a 4.6% higher fat mass and a 2.5% increased percentage fat mass compared to noncarriers; the results were significant after multiple testing correction. This same correlation was also seen in 700 independent Chinese Han adults and 1,000 additional Caucasians. This SNP therefore appears to be associated with risk for obesity.[PMID 18685868OA-icon.png]


[PMID 20217072OA-icon.png] SNP/haplotype associations in cytokine and cytokine receptor genes and immunity to rubella vaccine.