Have questions? Visit https://www.reddit.com/r/SNPedia

rs5751876

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 0 None
(C;T) 0 None
(T;T) 2.1 significantly higher anxiety levels after moderate caffeine consumption
ReferenceGRCh38 38.1/141
Chromosome22
Position24441333
GeneADORA2A, C22orf45
is asnp
is mentioned by
dbSNPrs5751876
ebirs5751876
HLIrs5751876
Exacrs5751876
Varsomers5751876
Maprs5751876
PheGenIrs5751876
hapmaprs5751876
1000 genomesrs5751876
hgdprs5751876
ensemblrs5751876
gopubmedrs5751876
geneviewrs5751876
scholarrs5751876
googlers5751876
pharmgkbrs5751876
gwascentralrs5751876
openSNPrs5751876
23andMers5751876
23andMe allrs5751876
SNP Nexus

SNPshotrs5751876
SNPdbers5751876
MSV3drs5751876
GWAS Ctlgrs5751876
GMAF0.4807
Max Magnitude2.1
Variation at this SNP, rs5751876, also referred to as 1976C>T or 1976T>C, appears to influence how an individual responds to moderate levels (150mg) of caffeine.

T/T carriers displaying significantly increased subjective levels of anxiety after consumption. [PMID 12825092] [PMID 18305461OA-icon.png]

However a PharmGKB variant annotation suggests it is (C;C) genotypes who are more sensitive to caffeine.

rs5751876 is not associated with how much coffee one drinks, though, nor with risk for Parkinson's disease, based on a study of 1,200 subjects.[PMID 18759349OA-icon.png]


[PMID 19902562] Purine biosynthetic pathway genes and methotrexate response in rheumatoid arthritis patients among north Indians


[PMID 20334879] Adenosine A(2A) receptor gene: Evidence for association of risk variants with panic disorder and anxious personality "rs2298383 shows functional potential based on in silico analyses and might therefore represent the true underlying causal variant"


[PMID 21658325] Adenosine A2A receptor polymorphisms in Korean patients with systemic sclerosis


[PMID 22012471OA-icon.png] ADORA2A Gene Variation, Caffeine, and Emotional Processing: A Multi-level Interaction on Startle Reflex


[PMID 22745815OA-icon.png] Affect-Modulated Startle: Interactive Influence of Catechol-O-Methyltransferase Val158Met Genotype and Childhood Trauma


[PMID 19565319] Adenosine A(2A) receptor gene (ADORA2A) variants may increase autistic symptoms and anxiety in autism spectrum disorder.


[PMID 19591938] A genetic variation in the ADORA2A gene modifies age at onset in Huntington's disease.


[PMID 20386734OA-icon.png] Further evidence supporting a role for gs signal transduction in severe malaria pathogenesis.


[PMID 20396431OA-icon.png] Genotyping sleep disorders patients.


[PMID 20520601OA-icon.png] Association of the anxiogenic and alerting effects of caffeine with ADORA2A and ADORA1 polymorphisms and habitual level of caffeine consumption.


[PMID 22336631] Caffeine increases tear volume depending on polymorphisms within the adenosine A2a receptor gene and cytochrome P450 1A2.


[PMID 23535492OA-icon.png] ADORA2A polymorphism predisposes children to encephalopathy with febrile status epilepticus


[PMID 23018769] A survey of putative anxiety-associated genes in panic disorder patients with and without bladder symptoms


[PMID 22940476] Effects of ADORA2A gene variation and caffeine on prepulse inhibition: a multi-level risk model of anxiety.


[PMID 23332182] A study of the possible association between adenosine A2A receptor gene polymorphisms and attention-deficit hyperactivity disorder traits.


[PMID 24943643OA-icon.png] Association of Adenosine Receptor Gene Polymorphisms and in vivo Adenosine A1 Receptor Binding in the Human Brain


[PMID 25629231OA-icon.png] The Association of ADORA2A and ADORA2B Polymorphisms with the Risk and Severity of Chronic Heart Failure: A Case-Control Study of a Northern Chinese Population


[PMID 26066465] Categorical complexities of Plasmodium falciparum malaria in individuals is associated with genetic variations in ADORA2A and GRK5 genes