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rs579459

From SNPedia

Orientationplus
Stabilizedplus
Make rs579459(C;C)
Make rs579459(C;T)
Make rs579459(T;T)
ReferenceGRCh38 38.1/141
Chromosome9
Position133278724
is asnp
is mentioned by
dbSNPrs579459
ebirs579459
HLIrs579459
Exacrs579459
Varsomers579459
Maprs579459
PheGenIrs579459
hapmaprs579459
1000 genomesrs579459
hgdprs579459
ensemblrs579459
gopubmedrs579459
geneviewrs579459
scholarrs579459
googlers579459
pharmgkbrs579459
gwascentralrs579459
openSNPrs579459
23andMers579459
23andMe allrs579459
SNP Nexus

SNPshotrs579459
SNPdbers579459
MSV3drs579459
GWAS Ctlgrs579459
GMAF0.1887
Max Magnitude
? (C;C) (C;T) (T;T) 28
GWAS snp
PMID [PMID 19729612OA-icon.png]
Trait Serum soluble E-selectin
Title Genome-Wide Association Identifies the ABO Blood Group as a Major Locus Associated With Serum Levels of Soluble E-Selectin
Risk Allele C
P-val 1E-29
Odds Ratio NR NR
GWAS snp
PMID [PMID 20167578OA-icon.png]
Trait Soluble levels of adhesion molecules
Title Large-scale genomic studies reveal central role of ABO in sP-selectin and sICAM-1 levels
Risk Allele T
P-val 2E-41
Odds Ratio 14.00 [12.04-15.96] % increase
GWAS snp
PMID [PMID 21378990OA-icon.png]
Trait
Title Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
Risk Allele C
P-val 4E-14
Odds Ratio 1.1000 [1.07-1.13]


[PMID 22010135OA-icon.png] Association of Variation at the ABO Locus with Circulating Levels of sICAM-1, sP-selectin and sE-selectin: A Meta-Analysis

GWAS snp
PMID [PMID 22001757OA-icon.png]
Trait
Title Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
Risk Allele T
P-val 3E-123
Odds Ratio 8.8000 None


GET Evidence
rs579459
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.140625
summary



Coronary Heart Disease

GWAS snp
PMID [PMID 23222517OA-icon.png]
Trait Red blood cell traits
Title Seventy-five genetic loci influencing the human red blood cell.
Risk Allele T
P-val 9E-18
Odds Ratio .02 [0.015-0.027] unit increase


[PMID 23161703] Influence of 23 coronary artery disease variants on recurrent myocardial infarction or cardiac death: the GRACE Genetics Study.

GWAS snp
PMID [PMID 24262325OA-icon.png]
Trait Coronary artery disease
Title Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.
Risk Allele C
P-val 2E-7
Odds Ratio 1.10 [1.06-1.14]
GWAS snp
PMID [PMID 24586186OA-icon.png]
Trait Urinary metabolites (H-NMR features)
Title Genome-wide association study of metabolic traits reveals novel gene-metabolite-disease links.
Risk Allele T
P-val 1E-28
Odds Ratio .49 [NR] unit increase
GWAS snp
PMID [PMID 24816252OA-icon.png]
Trait Blood metabolite ratios
Title An atlas of genetic influences on human blood metabolites.
Risk Allele T
P-val 1E-28
Odds Ratio .12 [0.1-0.15] unit decrease


[PMID 24251769] LDL-c-linked SNPs are associated with LDL-c and myocardial infarction despite lipid-lowering therapy in patients with established vascular disease


[PMID 26413716] A GWAS Study on Liver Function Test Using eMERGE Network Participants