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rs58597806

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(G;G) 0 normal
(G;T) 1.8 likely reduced UGT1A9 glucuronidation
(T;T) 2 likely reduced UGT1A9 glucuronidation
Make rs58597806(A;A)
Make rs58597806(A;G)
ReferenceGRCh38 38.1/141
Chromosome2
Position233672700
GeneUGT1A8, UGT1A9, UGT1A10
is asnp
is mentioned by
dbSNPrs58597806
ebirs58597806
HLIrs58597806
Exacrs58597806
Varsomers58597806
Maprs58597806
PheGenIrs58597806
hapmaprs58597806
1000 genomesrs58597806
hgdprs58597806
ensemblrs58597806
gopubmedrs58597806
geneviewrs58597806
scholarrs58597806
googlers58597806
pharmgkbrs58597806
gwascentralrs58597806
openSNPrs58597806
23andMers58597806
23andMe allrs58597806
SNP Nexus

SNPshotrs58597806
SNPdbers58597806
MSV3drs58597806
GWAS Ctlgrs58597806
Max Magnitude2
rs58597806 (Asp256Asn/D256N) is a SNP within UGT1A9 (UDP glucuronosyltransferase 1 family, polypeptide A9).

[PMID 18816295] reduced propofol glucuronidation - considerably lowered glucuronidation of mycophenolic acid, 1-naphthol, and naringenin. may be at risk adverse effects w/ propofol and other UGT1A9 substrate administration

[PMID 12730278] essentially non-functional with regard to SN-38 (7-ethyl-10-hydroxycamptothecin) glucuronidation, an active metabolite of irinotecan