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rs5882(A;A)

From SNPedia

Faster aging. Increased risk for Dementia. Less good cholesterol.
Is agenotype
ofrs5882
GeneCETP
Chromosome16
Position56,982,180
mentionedby
Magnitude2
ReputeBad
Geno Mag Summary
(A;A) 2 Faster aging. Increased risk for Dementia. Less good cholesterol.
(A;G) 2 Lower risk of dementia and Alzheimer's disease. Higher good cholesterol.
(G;G) 2.1 Longer lifespan, 0.28x lower risk of dementia, 0.31x lower risk of Alzheimer's.

This reduces HDL ("good") cholesterol. HDL cholesterol removes cholesterol from artery walls and improves health. This SNP seems to be associated with higher blood pressure, less longevity, and more diseases of aging, in particular memory decline and dementia, and lower odds of living to 100, especially in Ashkenazi Jews. Attempting to raise HDL cholesterol may (or may not) be useful to mitigate the effects of this SNP.