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rs5882(G;G)

From SNPedia

Longer lifespan, 0.28x lower risk of dementia, 0.31x lower risk of Alzheimer's.
Is agenotype
ofrs5882
GeneCETP
Chromosome16
Position56,982,180
mentionedby
Magnitude2.1
ReputeGood
Geno Mag Summary
(A;A) 2 Faster aging. Increased risk for Dementia. Less good cholesterol.
(A;G) 2 Lower risk of dementia and Alzheimer's disease. Higher good cholesterol.
(G;G) 2.1 Longer lifespan, 0.28x lower risk of dementia, 0.31x lower risk of Alzheimer's.

This SNP has been related to exceptional long life. A study in Ashkenazi Jews showed that individuals with this genotype have significantly longer lifespans, and better cognitive function. [PMID 17190939]) Another study shows that this homozygote has an average 70% lower risk of dementia and Alzheimer's disease. This SNP might work by raising HDL ("good") cholesterol and lowering blood pressure.