| Longer lifespan, 0.28x lower risk of dementia, 0.31x lower risk of Alzheimer's. |
| Geno
|
Mag
|
Summary
|
| (A;A)
|
2
|
Faster aging. Increased risk for Dementia. Less good cholesterol.
|
| (A;G)
|
2
|
Lower risk of dementia and Alzheimer's disease. Higher good cholesterol.
|
| (G;G)
|
2.1
|
Longer lifespan, 0.28x lower risk of dementia, 0.31x lower risk of Alzheimer's.
|
This SNP has been related to exceptional long life. A study in Ashkenazi Jews showed that individuals with this genotype have significantly longer lifespans, and better cognitive function. [PMID 17190939]) Another study shows that this homozygote has an average 70% lower risk of dementia and Alzheimer's disease. This SNP might work by raising HDL ("good") cholesterol and lowering blood pressure.
