|(C;C)||1.5||higher HDL cholesterol but lower risk for age-related macular degeneration|
|(C;T)||2.5||3x higher risk for age-related macular degeneration|
|(T;T)||2||lower HDL cholesterol but higher risk for age-related macular degeneration|
In a case-control study of two Caucasian populations totaling 2,498 patients, rs5888(C;T) heterozygotes had an increased odds ratio of 2.9 (CI: 1.6-5.3, p<0.002) for age-related macular degeneration (ARMD) based on a pooled analysis. Subgroup analysis indicated that the odds ratio for exudative forms of ARMD was even higher (3.6; CI: 1.7-7.6, p>0.0015) for rs5888(C;T) heterozygotes. [PMID 19806217]
[PMID 21531995] Clinical impact of scavenger receptor class B type I gene polymorphisms on human female fertility
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[PMID 19041386] Genetic-epidemiological evidence on genes associated with HDL cholesterol levels: a systematic in-depth review.
[PMID 19158204] Scavenger receptor class B type I protein as an independent predictor of high-density lipoprotein cholesterol levels in subjects with hyperalphalipoproteinemia.
[PMID 20060115] A synonymous variant in scavenger receptor, class B, type I gene is associated with lower SR-BI protein expression and function.
[PMID 20085651] Impact of gene variants on sex-specific regulation of human Scavenger receptor class B type 1 (SR-BI) expression in liver and association with lipid levels in a population-based study.
[PMID 20664795] R102G polymorphism of the C3 gene associated with exudative age-related macular degeneration in a French population.
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[PMID 23355348] Interactions of several single nucleotide polymorphisms and high body mass index on serum lipid traits.
[PMID 26754576] The rs5888 single nucleotide polymorphism in scavenger receptor class B type 1 (SCARB1) gene and the risk of premature coronary artery disease: a case-control study.
[PMID 27428740] SCARB1 rs5888 is associated with the risk of age-related macular degeneration susceptibility and an impaired macular area.