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rs5963409

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 1.19x increased risk for Alzheimer's disease
(A;G) 1.19x increased risk for Alzheimer's disease
(G;G) normal
ReferenceGRCh38 38.1/141
ChromosomeX
Position38351716
GeneOTC
is asnp
is mentioned by
dbSNPrs5963409
ebirs5963409
HLIrs5963409
Exacrs5963409
Varsomers5963409
Maprs5963409
PheGenIrs5963409
hapmaprs5963409
1000 genomesrs5963409
hgdprs5963409
ensemblrs5963409
gopubmedrs5963409
geneviewrs5963409
scholarrs5963409
googlers5963409
pharmgkbrs5963409
gwascentralrs5963409
openSNPrs5963409
23andMers5963409
23andMe allrs5963409
SNP Nexus

SNPshotrs5963409
SNPdbers5963409
MSV3drs5963409
GWAS Ctlgrs5963409
GMAF0.3071
Max Magnitude
rs5963409 is a SNP in the ornithine carbamoyltransferase OTC gene; this SNP is also known as the -389 G/A SNP.

Previous association studies were extended to a population of 2113 Alzheimer's disease cases and 1580 controls from northern France, western France, the United Kingdom and Italy. The rs5963409(A) minor allele was weakly but significantly associated with an increased risk of developing Alzheimer's disease (odds ratio 1.19, p = 0.004). This association was independent of age and ApoE status.[PMID 18983895]

[PMID 19574962] Association of Ornithine Transcarbamylase Gene Polymorphisms With Hypertension and Coronary Artery Vasomotion