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rs600491

From SNPedia

Orientationplus
Stabilizedplus
Make rs600491(C;C)
Make rs600491(C;T)
Make rs600491(T;T)
ReferenceGRCh38 38.1/141
Chromosome1
Position54867852
GeneDHCR24
is asnp
is mentioned by
dbSNPrs600491
ebirs600491
HLIrs600491
Exacrs600491
Varsomers600491
Maprs600491
PheGenIrs600491
hapmaprs600491
1000 genomesrs600491
hgdprs600491
ensemblrs600491
gopubmedrs600491
geneviewrs600491
scholarrs600491
googlers600491
pharmgkbrs600491
gwascentralrs600491
openSNPrs600491
23andMers600491
23andMe allrs600491
SNP Nexus

SNPshotrs600491
SNPdbers600491
MSV3drs600491
GWAS Ctlgrs600491
GMAF0.3788
Max Magnitude
? (C;C) (C;T) (T;T) 28

[PMID 17510943] men carrying the T allele of rs600491 had an increased risk of Alzheimer's disease (OR 1.7 95% CI 1.2-2.4; P = 0.004, Bonferroni corrected P = 0.048 with 12 tests).

[PMID 17510943] rs638944(T) and rs600491(C) protective haplotype TC with frequency of 0.22 in cases and 0.30 in controls (P < 0.001)

[PMID 17510943] rs638944(G) and rs600491(C) risk haplotype GC with frequency of 0.10 in cases and 0.05 in controls (P < 0.001)

[PMID 17510943] Alzheimer's disease cases that carry rs718265(G;G) had lower levels of Abeta(42)


[PMID 22910610] Gender dependent effect of DHCR24 polymorphism on the risk for Alzheimer's disease.