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rs6013029

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(G;G) 0 normal
(G;T) None
(T;T) None
ReferenceGRCh38 38.1/141
Chromosome20
Position37771178
GeneCTNNBL1
is asnp
is mentioned by
dbSNPrs6013029
ebirs6013029
HLIrs6013029
Exacrs6013029
Varsomers6013029
Maprs6013029
PheGenIrs6013029
hapmaprs6013029
1000 genomesrs6013029
hgdprs6013029
ensemblrs6013029
gopubmedrs6013029
geneviewrs6013029
scholarrs6013029
googlers6013029
pharmgkbrs6013029
gwascentralrs6013029
openSNPrs6013029
23andMers6013029
23andMe allrs6013029
SNP Nexus

SNPshotrs6013029
SNPdbers6013029
MSV3drs6013029
GWAS Ctlgrs6013029
GMAF0.0854
Max Magnitude0
? (G;G) (G;T) (T;T) 28
rs6013029 is a SNP in the CTNNBL1 gene.

[PMID 19228371OA-icon.png] Found no evidence of early onset obesity or increased body mass index association with this SNP in several populations (~3,000 cases overall) of Central European (German) ancestry.

While the older [PMID 18325910OA-icon.png] a study of ~1,900 Caucasians turned up associations between several SNPs in the CTNNBL1 gene and increased risk for obesity, of which rs6013029 was statistically the strongest, with an odds ratio of 1.42 for (T;T) homozgyotes compared to (G;G) homozygotes. This SNP achieved experiment-wise p values of 2.69 x 10-7 for body mass index (BMI) and of 4.99 x 10-8 for fat mass, respectively. The rs6013029(T) allele confers an average increase in BMI and fat mass of 2.67 kg/m(2) and 5.96 kg, respectively, compared to rs6013029(G).


[PMID 18852197OA-icon.png] Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants.


[PMID 19079261OA-icon.png] Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.


[PMID 19245693OA-icon.png] Studies of CTNNBL1 and FDFT1 variants and measures of obesity: analyses of quantitative traits and case-control studies in 18,014 Danes.


[PMID 20712903OA-icon.png] Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study.