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rs603965

From SNPedia

Merged intors9344
Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 0 normal
(A;G)  ?
(G;G) increased breast cancer risk
ReferenceGRCh38 38.1/141
Chromosome11
Position69648142
GeneCCND1, LOC100996515
is asnp
is mentioned by
dbSNPrs603965
ebirs603965
HLIrs603965
Exacrs603965
Varsomers603965
Maprs603965
PheGenIrs603965
hapmaprs603965
1000 genomesrs603965
hgdprs603965
ensemblrs603965
gopubmedrs603965
geneviewrs603965
scholarrs603965
googlers603965
pharmgkbrs603965
gwascentralrs603965
openSNPrs603965
23andMers603965
23andMe allrs603965
SNP Nexus

SNPshotrs603965
SNPdbers603965
MSV3drs603965
GWAS Ctlgrs603965
StatusMerged into rs9344
Max Magnitude0
? (A;A) (A;G) (G;G) 28
rs603965 is a SNP in the cyclin D1 CCND1 gene. It is also known as Pro241Pro. The associated genotypes are characterized in terms of their enzymatic activity as High for (A;A), Medium (A;G), and Low (G;G).

In a study of 2 populations of breast cancer patients (2,000+ patients), increased risk was associated with rs603965(A;A) genotypes in both the Ontario [odds ratio 2.22, CI: 1.49-3.28] and Finland [OR 1.73, CI: 1.08-2.78] populations.[PMID 18194538OA-icon.png]

GWAS snp
PMID [PMID 23502783]
Trait Multiple myeloma (IgH translocation)
Title The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma.
Risk Allele G
P-val 2E-11
Odds Ratio 1.95 [1.61-2.38]


[PMID 24264314] Association between CCND1 and XPC polymorphisms and bladder cancer risk: a meta-analysis based on 15 case-control studies


[PMID 27156331] SNP rs1059234 in CDKN1A Gene Correlates with Prognosis in Resected Gastric Adenocarcinoma.