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rs605059

From SNPedia

Orientationminus
Stabilizedminus
Make rs605059(C;C)
Make rs605059(C;T)
Make rs605059(T;T)
ReferenceGRCh38 38.1/141
Chromosome17
Position42554888
GeneHSD17B1
is asnp
is mentioned by
dbSNPrs605059
ebirs605059
HLIrs605059
Exacrs605059
Varsomers605059
Maprs605059
PheGenIrs605059
hapmaprs605059
1000 genomesrs605059
hgdprs605059
ensemblrs605059
gopubmedrs605059
geneviewrs605059
scholarrs605059
googlers605059
pharmgkbrs605059
gwascentralrs605059
openSNPrs605059
23andMers605059
23andMe allrs605059
SNP Nexus

SNPshotrs605059
SNPdbers605059
MSV3drs605059
GWAS Ctlgrs605059
GMAF0.4871
Max Magnitude

[PMID 20432167] Dietary isoflavone intake, polymorphisms in the CYP17, CYP19, 17beta-HSD1, and SHBG genes, and risk of breast cancer in case-control studies in Japanese, Japanese Brazilians, and non-Japanese Brazilians


[PMID 20586553] Polymorphisms in ESR1, ESR2 and HSD17B1 genes are associated with fertility status in endometriosis

[PMID 16489054] Haplotype analysis of the HSD17B1 gene and risk of breast cancer: a comprehensive approach to multicenter analyses of prospective cohort studies.

[PMID 17301695OA-icon.png] Interaction of soy and 17beta-HSD1 gene polymorphisms in the risk of endometrial cancer.

[PMID 18086758OA-icon.png] Association between single-nucleotide polymorphisms in hormone metabolism and DNA repair genes and epithelial ovarian cancer: results from two Australian studies and an additional validation set.

[PMID 18483327OA-icon.png] Polymorphisms in steroid hormone biosynthesis genes and risk of breast cancer and fibrocystic breast conditions in Chinese women.

[PMID 18805939OA-icon.png] Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis.

[PMID 18843021OA-icon.png] HSD17B1 genetic variants and hormone receptor-defined breast cancer.

[PMID 19015200OA-icon.png] Polymorphisms in estrogen- and androgen-metabolizing genes and the risk of gastric cancer.

[PMID 19679043OA-icon.png] African American-preponderant single nucleotide polymorphisms (SNPs) and risk of breast cancer.

[PMID 21429951] Quantitative trait analysis suggests polymorphisms of estrogen-related genes regulate human sperm concentrations and motility.

[PMID 22546946] Polymorphisms in genes HSD17B1 and HSD17B2 and uterine leiomyoma risk in Chinese women.


GET Evidence
HSD17B1-G313S
aa_change Gly313Ser
aa_change_short G313S
impact not reviewed
qualified_impact Insufficiently evaluated not reviewed
overall_frequency 0.597398
summary



[PMID 23430226] Confirmation of the reduction of hormone replacement therapy-related breast cancer risk for carriers of the HSD17B1_937_G variant.


[PMID 25394609] Evidence for association of the rs605059 polymorphism of HSD17B1 gene with recurrent spontaneous abortions


[PMID 27571989] 17β-hydroxysteroid dehydrogenase type Gene 1937 A > G Polymorphism as a Risk Factor for Cervical Cancer Progression in the Polish Population.