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rs610604

From SNPedia

Orientationminus
Stabilizedminus
Make rs610604(A;A)
Make rs610604(A;C)
Make rs610604(C;C)
ReferenceGRCh38 38.1/141
Chromosome6
Position137878280
GeneTNFAIP3
is asnp
is mentioned by
dbSNPrs610604
ebirs610604
HLIrs610604
Exacrs610604
Varsomers610604
Maprs610604
PheGenIrs610604
hapmaprs610604
1000 genomesrs610604
hgdprs610604
ensemblrs610604
gopubmedrs610604
geneviewrs610604
scholarrs610604
googlers610604
pharmgkbrs610604
gwascentralrs610604
openSNPrs610604
23andMers610604
23andMe allrs610604
SNP Nexus

SNPshotrs610604
SNPdbers610604
MSV3drs610604
GWAS Ctlgrs610604
GMAF0.3627
Max Magnitude
? (A;A) (A;C) (C;C) 28

23andMe blog psoriasis Europeans

  • rs610604(G) 1.19x risk
GWAS snp
PMID [PMID 19169254OA-icon.png]
Trait Psoriasis
Title Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways
Risk Allele G
P-val 9E-12
Odds Ratio 1.19 None


GWAS snp
PMID [PMID 20953190OA-icon.png]
Trait
Title A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1
Risk Allele
P-val 7E-7
Odds Ratio 1.2200 [1.13-1.32]


[PMID 21623003OA-icon.png] Confirmation of TNIP1 and IL23A as susceptibility loci for psoriatic arthritis


[PMID 22113471OA-icon.png] TNFAIP3 gene polymorphisms are associated with response to TNF blockade in psoriasis.


[PMID 17259397] Tag polymorphisms at the A20 (TNFAIP3) locus are associated with lower gene expression and increased risk of coronary artery disease in type 2 diabetes.


[PMID 19262574OA-icon.png] Genome-wide association scan yields new insights into the immunopathogenesis of psoriasis.


[PMID 21253569OA-icon.png] Genome-wide association study SNPs in the human genome diversity project populations: does selection affect unlinked SNPs with shared trait associations?


GET Evidence
rs610604
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.601562
summary



[PMID 23161053] TNFAIP3 gene polymorphisms confer risk for Behcet's disease in a Chinese Han population


[PMID 23521149] Pharmacogenetics of psoriasis: HLA-Cw6 but not LCE3B/3C deletion nor TNFAIP3 polymorphism predisposes to clinical response to interleukin 12/23 blocker ustekinumab.


[PMID 25496073] The TNFAIP3 polymorphism rs610604 both associates with the risk of psoriasis vulgaris and affects the clinical severity


[PMID 26005883] Lack of association of TNFAIP3 and JAK1 with Behçet's disease in the European population