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rs6123837

From SNPedia

Orientationplus
Stabilizedplus
Make rs6123837(A;A)
Make rs6123837(A;G)
Make rs6123837(G;G)
ReferenceGRCh38 38.1/141
Chromosome20
Position58890516
GeneGNAS, LOC101927932
is asnp
is mentioned by
dbSNPrs6123837
ebirs6123837
HLIrs6123837
Exacrs6123837
Varsomers6123837
Maprs6123837
PheGenIrs6123837
hapmaprs6123837
1000 genomesrs6123837
hgdprs6123837
ensemblrs6123837
gopubmedrs6123837
geneviewrs6123837
scholarrs6123837
googlers6123837
pharmgkbrs6123837
gwascentralrs6123837
openSNPrs6123837
23andMers6123837
23andMe allrs6123837
SNP Nexus

SNPshotrs6123837
SNPdbers6123837
MSV3drs6123837
GWAS Ctlgrs6123837
GMAF0.3779
Max Magnitude
? (A;A) (A;G) (G;G) 28
rs6123837 ( G(-1211)A ) is a SNP within GNAS (GNAS complex locus - encoding the Gs alpha subunit).

[PMID 18192900] among a group of 110 individuals participating in a randomized placebo-controlled weight loss trial (and under a low calorie diet)...

  • those with GG genotypes lost significantly more weight compared to A allele carriers
  • sibutramine was effective only in A allele carriers for weight loss, however, carriers for two Gs showed the strongest increases in resting heart rate and systolic blood pressure


[PMID 19593725OA-icon.png] Association of maternally inherited GNAS alleles with African-American male birth weight.


[PMID 23065660] GNAS A-1121G variant is associated with improved diastolic dysfunction in response to exercise training in heart failure patients.