Rs6152

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baldness
Orientationplus
is asnp
is mentioned by
dbSNPrs6152
PheGenIrs6152
nextbiors6152
hapmaprs6152
1000 genomesrs6152
hgdprs6152
ensemblrs6152
gopubmedrs6152
geneviewrs6152
scholarrs6152
googlers6152
pharmgkbrs6152
gwascentralrs6152
openSNPrs6152
23andMers6152
23andMe allrs6152
SNP Nexus

SNPshotrs6152
SNPdbers6152
MSV3drs6152
GeneAR
ChromosomeX
Orientationplus
GMAF0.2146
Position66765627
ReferenceGRCh37 37.1/132
Max Magnitude4
Geno Mag Summary
(A;) 3
(A;A) 4 won't go bald
(A;G) 2 if male, won't go bald
(G;G) 0.5 able to go bald
? (A;A) (A;G) (G;G) 28
rs6152, located in the first exon of the androgen receptor AR gene located on the X chromosome, is highly indicative of the ability to develop male pattern baldness. The risk allele is (G). However, although it appears to be necessary for baldness to develop, other (as yet unknown) variations must also be present for baldness to actually occur. [PMID 11231320], [PMID 17256155]

Since this SNP is on the X chromosome, and affects a trait primarily seen only in males, a single allele is shown as representing the individual's genotype. However, baldness may also occur in females, presumably only in females homozygous for rs6152(G;G) and also harboring the (as yet unknown) additional variations required for baldness.

Note: The colorful and informative Figure 1 in [PMID 17256155] shows the probability of varying degrees of baldness as men age depending on whether they are rs6152(A) or rs6152(G).

Note: A subsequent study has found that rs1160312 may be an important additional variant acting in conjunction with rs6152 to influence baldness.

[PMID 15902657OA-icon.png] baldness

  • lowest P value of 2.1×10-12 for rs10521339
  • family based rs938059 shows the lowest P value (4.03×10-6) (table 3)
  • rs6152 (P=6.66×10-10)
OMIM300710
DescALOPECIA, ANDROGENETIC, 2; AGA2
Variant
Relatedalso


[PMID 21981665] Androgen receptor gene polymorphisms and risk for androgenetic alopecia: a meta-analysis


[PMID 15570555OA-icon.png] Systematic evaluation of genetic variation at the androgen receptor locus and risk of prostate cancer in a multiethnic cohort study.


[PMID 15994977OA-icon.png] Androgen receptor cytosine, adenine, guanine repeats, and haplotypes in relation to ovarian cancer risk.


[PMID 16987421OA-icon.png] A comprehensive analysis of the androgen receptor gene and risk of breast cancer: results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3).


[PMID 18385763] EDA2R is associated with androgenetic alopecia.


[PMID 19167832] Possible association between the androgen receptor gene and autism spectrum disorder.


[PMID 19190146OA-icon.png] Genetic variation in the androgen receptor gene and endometrial cancer risk.


[PMID 19555469OA-icon.png] A prospective study of androgen levels, hormone-related genes and risk of rheumatoid arthritis.


[PMID 20450840] Association of AR rs6152G/A gene polymorphism with susceptibility to polycystic ovary syndrome in Chinese women.


[PMID 23441776] Androgen receptor genetic variants in male patients with ankylosing spondylitis in Taiwan