, also known as Q170H or Gln170His, is a SNP in the ADAM metallopeptidase domain 10 ADAM10
gene. The common allele is rs61751103
(C) (in the FWD direction, not in the mRNA), encoding the Gln.
[PMID 19608551] The rs61751103(G) allele was found in 11 of 16 individuals affected by Alzheimer's disease (average onset age 69.5 years) from seven late-onset AD families. This mutation was also found in at least one unaffected subject, implying incomplete penetrance.
This SNP is referred to as i6006818 by 23andMe.