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rs6198

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(A;A) 0
Make rs6198(A;G)
Make rs6198(G;G)
ReferenceGRCh38 38.1/142
Chromosome5
Position143278056
GeneNR3C1
is asnp
is mentioned by
dbSNPrs6198
ebirs6198
HLIrs6198
Exacrs6198
Varsomers6198
Maprs6198
PheGenIrs6198
hapmaprs6198
1000 genomesrs6198
hgdprs6198
ensemblrs6198
gopubmedrs6198
geneviewrs6198
scholarrs6198
googlers6198
pharmgkbrs6198
gwascentralrs6198
openSNPrs6198
23andMers6198
23andMe allrs6198
SNP Nexus

SNPshotrs6198
SNPdbers6198
MSV3drs6198
GWAS Ctlgrs6198
GMAF0.09229
Max Magnitude0
? (A;A) (A;G) (G;G) 28
rs6198 (A3669G) is a SNP located within exon 9 beta of the NR3C1 (Nuclear receptor subfamily 3, group C, member 1 [glucocorticoid receptor]) gene.

[PMID 18663733] rs10482605(C) and rs6198 form a haplotype responsible for both regulation of glucocorticoid expression and mRNA stability and therefore theorized to be associated with major depression.

journal significant blood pressure associations of a haplotype that is distinguished by rs6198 A/G.


[PMID 20440229] Glucocorticoid receptor gene polymorphisms in Italian patients with eating disorders and obesity

[PMID 20547006] FKBP5 and resistant attachment predict cortisol reactivity in infants: Gene-environment interaction


[PMID 21164266] Glucocorticoid resistance


[PMID 22507373] Glucocorticoid receptor gene polymorphisms are associated with reduced first-phase glucose-stimulated insulin secretion and disposition index in women, but not in men


[PMID 18830906] Glucocorticoid receptor variants may predispose to rheumatoid arthritis susceptibility.

[PMID 17532759OA-icon.png] Glucocorticoid receptor gene polymorphisms and susceptibility to rheumatoid arthritis.

[PMID 18854398OA-icon.png] Glucocorticoid receptor gene variant in the 3' untranslated region is associated with multiple measures of blood pressure.

[PMID 20199670OA-icon.png] Glucocorticoid receptor gene polymorphisms do not affect growth in fetal and early postnatal life. The Generation R Study.

[PMID 20680430OA-icon.png] No associations between single nucleotide polymorphisms in corticoid receptor genes and heart rate and cortisol responses to a standardized social stress test in adolescents: the TRAILS study.

[PMID 21146942] Glucocorticoid receptor-9beta polymorphism is associated with systolic blood pressure and heart growth during early childhood. The Generation R Study.

[PMID 21232135OA-icon.png] Glucocorticoid receptor gene polymorphism and juvenile idiopathic arthritis.

[PMID 21448414OA-icon.png] Molecular mechanism of glucocorticoid resistance in inflammatory bowel disease.

[PMID 21764460] Glucocorticoid receptor polymorphism is associated with major depression and predominance of depression in the course of bipolar disorder.

[PMID 21803757] Genetic polymorphisms of the glucocorticoid receptor may affect the phenotype of women with anovulatory polycystic ovary syndrome.

[PMID 21876507] Glucocorticoid receptor polymorphism is associated with lithium response in bipolar patients.

[PMID 22083731] Genetic modulation of neural response during working memory in healthy individuals: interaction of glucocorticoid receptor and dopaminergic genes.


[PMID 22781842OA-icon.png] Variation in the glucocorticoid receptor gene at rs41423247 moderates the effect of prenatal maternal psychological symptoms on child cortisol reactivity and behavior


[PMID 23055001] Genetic evidence for the association of the hypothalamic-pituitary-adrenal (HPA) axis with ADHD and methylphenidate treatment response.


[PMID 23543128] MR and GR functional SNPs may modulate tobacco smoking susceptibility.


[PMID 24856550] FKBP5 polymorphism is associated with major depression but not with bipolar disorder


[PMID 25644744] Single Nucleotide Polymorphisms in the Non-coding Region of the Glucocorticoid Receptor Gene and Prednisone Response in Childhood Acute Lymphoblastic Leukemia


[PMID 25724472OA-icon.png] Polymorphisms in the glucocorticoid receptor gene and in the glucocorticoid-induced transcript 1 gene are associated with disease activity and response to glucocorticoid bridging therapy in rheumatoid arthritis


[PMID 25843653] GLCCI1 and Glucocorticoid Receptor Genetic Diversity and Response to Glucocorticoid-Based Treatment of Graft-versus-Host Disease.