rs62527607(T) – which creates a RUNX1 binding site in the BAALC promoter region. This gene is often overactive, or overexpressed, in people with acute myeloid leukemia
or acute lymphoblastic leukemia, and it indicates that the disease is likely to respond poorly to standard therapy.
[PMID 22493267] Heritable polymorphism predisposes to high BAALC expression in acute myeloid leukemia.
news miR-3151, not BAALC is probably the risk factor for AML.
[PMID 27372260] Evaluation of rs62527607 [GT] single nucleotide polymorphism located in BAALC gene in children with acute leukemia using mismatch PCR-RFLP.