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rs6265(A;A)

From SNPedia

introversion; depression resistant; impaired motor skills learning
Is agenotype
ofrs6265
GeneBDNF, BDNF-AS
Chromosome11
Position27,658,369
mentionedby
Magnitude2.6
ReputeBad
Geno Mag Summary
(A;A) 2.6 introversion; depression resistant; impaired motor skills learning
(A;G) 2.6 Slightly increased risk for ADHD or depression
(G;G) 0 common/normal

Met/Met (higher risk) variant of the Val66Met SNP in the BDNF gene that codes for brain-derived neurotrophic factor. Met/Met is associated in some (but not all) studies with slightly increased susceptibility to certain mental health disorders such as ADHD and depression.

[PMID 20042999] associated with introversion

This genotype may provide resistance to depression when subjected to repeated defeat blog summary

On a driving-based motor learning task subjects with this genotype showed greater error during short-term learning and poorer retention over 4 days, relative to subjects without the polymorphism. The presence of this BDNF polymorphism is associated with differences in brain motor system function, altered short-term plasticity, and greater error in short-term motor learning. [PMID 19745020]

Wired discusses the research as does 23andMe blog.