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rs6267

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(G;G) 0 common
(G;T) None
(T;T) None
ReferenceGRCh38 38.1/141
Chromosome22
Position19962740
GeneCOMT, MIR4761
is asnp
is mentioned by
dbSNPrs6267
ebirs6267
HLIrs6267
Exacrs6267
Varsomers6267
Maprs6267
PheGenIrs6267
hapmaprs6267
1000 genomesrs6267
hgdprs6267
ensemblrs6267
gopubmedrs6267
geneviewrs6267
scholarrs6267
googlers6267
pharmgkbrs6267
gwascentralrs6267
openSNPrs6267
23andMers6267
23andMe allrs6267
SNP Nexus

SNPshotrs6267
SNPdbers6267
MSV3drs6267
GWAS Ctlgrs6267
GMAF0.01699
Max Magnitude0
? (G;G) (G;T) (T;T) 28
OMIM116790
DescSCHIZOPHRENIA, SUSCEPTIBILITY TO
Variant0002
Relatedalso
Neighborrs4633
Distance28
Neighborrs4818
Distance944
[PMID 19365560OA-icon.png] Low enzymatic activity haplotypes of the human catechol-O-methyltransferase gene: enrichment for marker SNPs

[PMID 19881467] Association analysis of COMT polymorphisms with schizophrenia and smooth pursuit eye movement abnormality



ClinVar
Risk rs6267(A,T;A,T)
Alt rs6267(A,T;A,T)
Reference rs6267(G;G)
Significance Other
Disease Schizophrenia
Variation info
Gene COMT MIR4761
CLNDBN Schizophrenia, susceptibility to
Reversed 0
HGVS NC_000022.10:g.19950263G>T
CLNSRC OMIM Allelic Variant
CLNACC RCV000019157.2,



[PMID 15645182] Association of Ala72Ser polymorphism with COMT enzyme activity and the risk of schizophrenia in Koreans.


[PMID 17363961] Clinical involvement of catechol-O-methyltransferase polymorphisms in schizophrenia spectrum disorders: influence on the severity of psychotic symptoms and on the response to neuroleptic treatment.


[PMID 17482701] No associations exist between five functional polymorphisms in the catechol-O-methyltransferase gene and schizophrenia in a Japanese population.


[PMID 19329282] Meta-analysis of association between genetic variants in COMT and schizophrenia: an update.


[PMID 21342622] [Catechol-O-methyltransferase gene rs6267 polymorphism in children with attention deficit hyperactivity disorder].


[PMID 21462137] [An association study of COMT gene polymorphisms with schizophrenia].