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rs6269

From SNPedia

Orientationplus
Stabilizedplus
Make rs6269(A;A)
Make rs6269(A;G)
Make rs6269(G;G)
ReferenceGRCh38 38.1/141
Chromosome22
Position19962429
GeneCOMT, MIR4761
is asnp
is mentioned by
dbSNPrs6269
ebirs6269
HLIrs6269
Exacrs6269
Varsomers6269
Maprs6269
PheGenIrs6269
hapmaprs6269
1000 genomesrs6269
hgdprs6269
ensemblrs6269
gopubmedrs6269
geneviewrs6269
scholarrs6269
googlers6269
pharmgkbrs6269
gwascentralrs6269
openSNPrs6269
23andMers6269
23andMe allrs6269
SNP Nexus

SNPshotrs6269
SNPdbers6269
MSV3drs6269
GWAS Ctlgrs6269
GMAF0.3719
Max Magnitude

[PMID 19290789] Association studies of catechol-O-methyltransferase (COMT) gene with schizophrenia and response to antipsychotic treatment


[PMID 19605537OA-icon.png] Effects of Catechol-O-Methyltransferase on Normal Variation in the Cognitive Function of Children



[PMID 20570835] No evidence for a role of the catechol-O-methyltransferase pain sensitivity haplotypes in chronic widespread pain


[PMID 21300128] COMT Val158met variant and functional haplotypes associated with childhood ADHD history in women with bulimia nervosa


[PMID 21884617OA-icon.png] Association of COMT genotypes with S-COMT promoter methylation in growth-discordant monozygotic twins and healthy adults


[PMID 21940152] The impact of COMT gene polymorphisms on suicidality in treatment resistant major depressive disorder - A European Multicenter Study


[PMID 22451510] Catechol-O-Methyltransferase Gene and Executive Function in Children With ADHD


[PMID 22528689] Pain sensitivity in fibromyalgia is associated with catechol-O-methyltransferase (COMT) gene


[PMID 22178088OA-icon.png] Catechol-O-methyltransferase (COMT) single nucleotide polymorphisms and haplotypes are not major risk factors for polycystic ovary syndrome


[PMID 16848906OA-icon.png] Genetic polymorphisms in monoamine neurotransmitter systems show only weak association with acute post-surgical pain in humans.


[PMID 17961261OA-icon.png] Catechol-O-methyltransferase gene haplotypes in Mexican and Spanish patients with fibromyalgia.


[PMID 18574484OA-icon.png] The complex global pattern of genetic variation and linkage disequilibrium at catechol-O-methyltransferase.


[PMID 18698234] The association of functional catechol-O-methyltransferase haplotypes with risk of Parkinson's disease, levodopa treatment response, and complications.


[PMID 18802928] Association between catechol O-methyltransferase (COMT) haplotypes and severity of hyperactivity symptoms in adults.


[PMID 19094200OA-icon.png] Genetic variation in the catechol-O-methyltransferase (COMT) gene and morphine requirements in cancer patients with pain.


[PMID 19193196OA-icon.png] Genetic contributions to pain: a review of findings in humans.


[PMID 19772600OA-icon.png] A comparison of classification methods for predicting Chronic Fatigue Syndrome based on genetic data.


[PMID 20531207] The impact of catechol-O-methyltransferase SNPs and haplotypes on treatment response phenotypes in major depressive disorder: a case-control association study.


[PMID 20627703] The association of single nucleotide polymorphisms in the catechol-O-methyltransferase gene and pain scores in female patients with major depressive disorder.


[PMID 20842020] Catecholamine-o-methyltransferase polymorphisms are associated with postoperative pain intensity.


[PMID 20863768] Association of catechol-O-methyltransferase genetic variants with outcome in patients undergoing surgical treatment for lumbar degenerative disc disease.


[PMID 21304959OA-icon.png] Epistasis between COMT and MTHFR in maternal-fetal dyads increases risk for preeclampsia.


[PMID 21355050OA-icon.png] A low COMT activity haplotype is associated with recurrent preeclampsia in a Norwegian population cohort (HUNT2).


[PMID 21423693OA-icon.png] Effect sizes in experimental pain produced by gender, genetic variants and sensitization procedures.


[PMID 21462137] [An association study of COMT gene polymorphisms with schizophrenia].


GET Evidence
rs6269
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.382812
summary



[PMID 22890010] Association of COMT, MTHFR, and SLC19A1(RFC-1) polymorphisms with homocysteine blood levels and cognitive impairment in Parkinson's disease.


[PMID 23178897OA-icon.png] The catechol-O-methyltransferase gene (COMT) and cognitive function from childhood through adolescence.


[PMID 24593143OA-icon.png] Genetic polymorphisms of catechol-O-methyltransferase modify the neurobehavioral effects of mercury in children


[PMID 26849490] Association between catechol-O-methyl transferase gene polymorphisms and fibromyalgia in a Korean population: A case-control study.


[PMID 27228319] A Tetra-Primer Amplification Refractory System Technique for the Cost-Effective and Novel Genotyping of Eight Single-Nucleotide Polymorphisms of the Catechol-O-Methyltransferase Gene.