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From SNPedia

Geno Mag Summary
(G;G) 0 common in clinvar
Make rs6295(C;C)
Make rs6295(C;G)
ReferenceGRCh38 38.1/141
is asnp
is mentioned by
1000 genomesrs6295
23andMe allrs6295
SNP Nexus

GWAS Ctlgrs6295
Max Magnitude0

[PMID 25412229OA-icon.png] The association between romantic relationship status and 5-HT1A gene in young adults.

[PMID 19358877OA-icon.png] Imaging Phenotypes of Major Depressive Disorder: Genetic Correlates

[PMID 19326813] A preliminary pharmacogenetic investigation of adverse events from topiramate in heavy drinkers

[PMID 19560507] Interaction of serotonin-related genes affects short-term antidepressant response in major depressive disorder

[PMID 19725031] Significant association between the C(-1019)G functional polymorphism of the HTR(1A) gene and impulsivity

[PMID 19590397] 5-HTR1A, 5-HTR2A, 5-HTR6, TPH1 and TPH2 polymorphisms and major depression

[PMID 19894072] A gene-environment investigation on personality traits in two independent clinical sets of adult patients with personality disorder and attention deficit/hyperactive disorder

[PMID 20043001OA-icon.png] Risk-Taking Behavior in a Gambling Task Associated with Variations in the Tryptophan Hydroxylase 2 Gene: Relevance to Psychiatric Disorders

[PMID 19897250] An association study of the serotonin transporter and receptor genes with the suicidal ideation of major depression in a Chinese Han population

[PMID 19730445] Serotonin 1A receptor gene and major depressive disorder: an association study and meta-analysis

[PMID 19747927] Serotonin 1A receptor gene is associated with Japanese methamphetamine-induced psychosis patients

[PMID 20594600] Serotonin 1A receptor gene, schizophrenia and bipolar disorder: An association study and meta-analysis

[PMID 21449006] Role of COMT, 5-HT(1A) , and SERT genetic polymorphisms on antidepressant response to transcranial magnetic stimulation

[PMID 21619616OA-icon.png] Transcriptional dysregulation of 5-HT1A autoreceptors in mental illness

[PMID 22232550OA-icon.png] Deaf-1 knockout mice display increased 5-HT1A autoreceptor expression and reduced raphe serotonin levels

[PMID 22826341OA-icon.png] Transcriptional regulation of the 5-HT1A receptor: implications for mental illness

[PMID 16626484OA-icon.png] The serotonin 1A receptor C(-1019)G polymorphism in relation to suicide attempt.

[PMID 17192951] HTR2C and HTR1A gene variants in German and Italian suicide attempters and completers.

[PMID 18081710OA-icon.png] Multivariate permutation analysis associates multiple polymorphisms with subphenotypes of major depression.

[PMID 18163385OA-icon.png] Association study between the serotonin 1A receptor (HTR1A) gene and neuroticism, major depression, and anxiety disorders.

[PMID 18308786] The --1019 C/G polymorphism of the 5-HT(1)A receptor gene is associated with negative symptom response to risperidone treatment in schizophrenia patients.

[PMID 18387137] 5-HT1A receptor gene C -1019 G polymorphism and amygdala volume in borderline personality disorder.

[PMID 18715570] Serotonin receptor HTR1A and HTR2C variants and personality traits in suicide attempters and controls.

[PMID 18848359] The combined effects of the 5-HTTLPR and 5-HTR1A genes modulates the relationship between negative life events and major depressive disorder in a Chinese population.

[PMID 19124686OA-icon.png] Effects of HTR1A C(-1019)G on amygdala reactivity and trait anxiety.

[PMID 19359258OA-icon.png] Cohort profile: risk patterns and processes for psychopathology emerging during adolescence: the ROOTS project.

[PMID 19428959OA-icon.png] 5-HT(1A) receptor function in major depressive disorder.

[PMID 19829169OA-icon.png] SSRI response in depression may be influenced by SNPs in HTR1B and HTR1A.

[PMID 19997044] No association between the serotonin-1A receptor gene single nucleotide polymorphism rs6295C/G and symptoms of anxiety or depression, and no interaction between the polymorphism and environmental stressors of childhood anxiety or recent stressful life events on anxiety or depression.

[PMID 20008943OA-icon.png] Association of FKBP5 polymorphisms with suicidal events in the Treatment of Resistant Depression in Adolescents (TORDIA) study.

[PMID 20454985] Associations between the serotonin-1A receptor C(-1019)G polymorphism and disordered eating symptoms in female adolescents.

[PMID 20638825] The HTR1A and HTR1B receptor genes influence stress-related information processing.

[PMID 21172166OA-icon.png] Pharmacogenetics of antidepressant response.

[PMID 21208417OA-icon.png] International Study to Predict Optimized Treatment for Depression (iSPOT-D), a randomized clinical trial: rationale and protocol.

[PMID 21621273OA-icon.png] Association of polymorphisms in HTR2A, HTR1A and TPH2 genes with suicide attempts in alcohol dependence: a preliminary report.

[PMID 22064163] Sertraline (Zoloft) response in major depressive disorder is not associated with three 5-HT1A receptor gene polymorphisms (rs6295, rs10042486, or rs1364043) in Chinese-Han patients.

[PMID 22392387] No association between the HTR1A gene and suicidal behavior: a meta-analysis.

GET Evidence
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.516129

[PMID 23192369] Relationship Between Genetic Polymorphisms in the HTR1A Gene and Paranoid Schizophrenia in a Northern Han Chinese Population

[PMID 23269215] Beyond Structural Equation Modeling: model properties and effect size from a Bayesian viewpoint. An example of complex phenotype - genotype associations in depression

[PMID 23798967OA-icon.png] No Effect of Serotoninergic Gene Variants on Response to Interpersonal Counseling and Antidepressants in Major Depression

[PMID 23499153] Genetic polymorphisms of serotonin transporter and receptor 1A could influence success during embryo implantation and maintenance of pregnancy

[PMID 23318131] Association of serotonin-1A and -2A receptor promoter polymorphisms with depressive symptoms, functional recovery, and pain in patients 6 months after lumbar disc surgery

[PMID 24158751] The effect of serotonin 1A receptor polymorphism on the cognitive function of premenstrual dysphoric disorder

[PMID 24304270] Regulatory variant of the TPH2 gene and early life stress are associated with heightened attention to social signals of fear in infants

[PMID 22727709] Evaluation of genetic models for response in a randomized clinical trial of duloxetine in major depressive disorder.

[PMID 22752684] The serotonin 1A receptor gene confer susceptibility to mood disorders: results from an extended meta-analysis of patients with major depression and bipolar disorder.

[PMID 22890315] Association between the 5-HT1A receptor gene polymorphism (rs6295) and antidepressants: a meta-analysis.

[PMID 23036158] The combined effects of the 5- HTTLPR and HTR1A rs6295 polymorphisms modulate decision making in schizophrenia patients.

[PMID 23333373] Rs6295 promoter variants of the serotonin type 1A receptor are differentially activated by c-Jun in vitro and correlate to transcript levels in human epileptic brain tissue.

[PMID 23375453] Genetic association of 5-HT1A and 5-HT1B gene polymorphisms with migraine in a Turkish population.

[PMID 23547754] Genetics of serotonin receptors and depression: state of the art.

[PMID 23733030] Pharmacogenetics in major depression: a comprehensive meta-analysis.

[PMID 25247748] Serotonin receptor gene (5-HT1A) modulates alexithymic characteristics and attachment orientation

[PMID 25990886] Impact of monoamine-related gene polymorphisms on hippocampal volume in treatment-resistant depression

[PMID 24021217OA-icon.png] Common selective serotonin reuptake inhibitor side effects in older adults associated with genetic polymorphisms in the serotonin transporter and receptors: data from a randomized controlled trial

[PMID 26544898] The impact of serotonin receptor 1A and 2A gene polymorphisms and interactions on suicide attempt and suicide risk in depressed patients with insufficient response to treatment - a European multicentre study

Risk rs6295(C;C)
Alt rs6295(C;C)
Reference rs6295(G;G)
Significance Drug-response
Disease paroxetine response - Efficacy
Variation info
Gene HTR1A
CLNDBN paroxetine response - Efficacy
Reversed 1
HGVS NC_000005.9:g.63258565C\x3d
CLNSRC PharmGKB Clinical Annotation PharmGKB
CLNACC RCV000211414.1,