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rs6295

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(G;G) 0 common in clinvar
Make rs6295(C;C)
Make rs6295(C;G)
ReferenceGRCh38 38.1/141
Chromosome5
Position63962738
GeneHTR1A
is asnp
is mentioned by
dbSNPrs6295
ebirs6295
HLIrs6295
Exacrs6295
Varsomers6295
Maprs6295
PheGenIrs6295
hapmaprs6295
1000 genomesrs6295
hgdprs6295
ensemblrs6295
gopubmedrs6295
geneviewrs6295
scholarrs6295
googlers6295
pharmgkbrs6295
gwascentralrs6295
openSNPrs6295
23andMers6295
23andMe allrs6295
SNP Nexus

SNPshotrs6295
SNPdbers6295
MSV3drs6295
GWAS Ctlgrs6295
GMAF0.4789
Max Magnitude0

[PMID 25412229OA-icon.png] The association between romantic relationship status and 5-HT1A gene in young adults.

[PMID 19358877OA-icon.png] Imaging Phenotypes of Major Depressive Disorder: Genetic Correlates

[PMID 19326813] A preliminary pharmacogenetic investigation of adverse events from topiramate in heavy drinkers

[PMID 19560507] Interaction of serotonin-related genes affects short-term antidepressant response in major depressive disorder

[PMID 19725031] Significant association between the C(-1019)G functional polymorphism of the HTR(1A) gene and impulsivity

[PMID 19590397] 5-HTR1A, 5-HTR2A, 5-HTR6, TPH1 and TPH2 polymorphisms and major depression

[PMID 19894072] A gene-environment investigation on personality traits in two independent clinical sets of adult patients with personality disorder and attention deficit/hyperactive disorder


[PMID 20043001OA-icon.png] Risk-Taking Behavior in a Gambling Task Associated with Variations in the Tryptophan Hydroxylase 2 Gene: Relevance to Psychiatric Disorders

[PMID 19897250] An association study of the serotonin transporter and receptor genes with the suicidal ideation of major depression in a Chinese Han population

[PMID 19730445] Serotonin 1A receptor gene and major depressive disorder: an association study and meta-analysis

[PMID 19747927] Serotonin 1A receptor gene is associated with Japanese methamphetamine-induced psychosis patients

[PMID 20594600] Serotonin 1A receptor gene, schizophrenia and bipolar disorder: An association study and meta-analysis





[PMID 21449006] Role of COMT, 5-HT(1A) , and SERT genetic polymorphisms on antidepressant response to transcranial magnetic stimulation


[PMID 21619616OA-icon.png] Transcriptional dysregulation of 5-HT1A autoreceptors in mental illness


[PMID 22232550OA-icon.png] Deaf-1 knockout mice display increased 5-HT1A autoreceptor expression and reduced raphe serotonin levels


[PMID 22826341OA-icon.png] Transcriptional regulation of the 5-HT1A receptor: implications for mental illness

[PMID 16626484OA-icon.png] The serotonin 1A receptor C(-1019)G polymorphism in relation to suicide attempt.


[PMID 17192951] HTR2C and HTR1A gene variants in German and Italian suicide attempters and completers.


[PMID 18081710OA-icon.png] Multivariate permutation analysis associates multiple polymorphisms with subphenotypes of major depression.


[PMID 18163385OA-icon.png] Association study between the serotonin 1A receptor (HTR1A) gene and neuroticism, major depression, and anxiety disorders.


[PMID 18308786] The --1019 C/G polymorphism of the 5-HT(1)A receptor gene is associated with negative symptom response to risperidone treatment in schizophrenia patients.


[PMID 18387137] 5-HT1A receptor gene C -1019 G polymorphism and amygdala volume in borderline personality disorder.


[PMID 18715570] Serotonin receptor HTR1A and HTR2C variants and personality traits in suicide attempters and controls.


[PMID 18848359] The combined effects of the 5-HTTLPR and 5-HTR1A genes modulates the relationship between negative life events and major depressive disorder in a Chinese population.


[PMID 19124686OA-icon.png] Effects of HTR1A C(-1019)G on amygdala reactivity and trait anxiety.


[PMID 19359258OA-icon.png] Cohort profile: risk patterns and processes for psychopathology emerging during adolescence: the ROOTS project.


[PMID 19428959OA-icon.png] 5-HT(1A) receptor function in major depressive disorder.


[PMID 19829169OA-icon.png] SSRI response in depression may be influenced by SNPs in HTR1B and HTR1A.


[PMID 19997044] No association between the serotonin-1A receptor gene single nucleotide polymorphism rs6295C/G and symptoms of anxiety or depression, and no interaction between the polymorphism and environmental stressors of childhood anxiety or recent stressful life events on anxiety or depression.


[PMID 20008943OA-icon.png] Association of FKBP5 polymorphisms with suicidal events in the Treatment of Resistant Depression in Adolescents (TORDIA) study.


[PMID 20454985] Associations between the serotonin-1A receptor C(-1019)G polymorphism and disordered eating symptoms in female adolescents.


[PMID 20638825] The HTR1A and HTR1B receptor genes influence stress-related information processing.


[PMID 21172166OA-icon.png] Pharmacogenetics of antidepressant response.


[PMID 21208417OA-icon.png] International Study to Predict Optimized Treatment for Depression (iSPOT-D), a randomized clinical trial: rationale and protocol.


[PMID 21621273OA-icon.png] Association of polymorphisms in HTR2A, HTR1A and TPH2 genes with suicide attempts in alcohol dependence: a preliminary report.


[PMID 22064163] Sertraline (Zoloft) response in major depressive disorder is not associated with three 5-HT1A receptor gene polymorphisms (rs6295, rs10042486, or rs1364043) in Chinese-Han patients.


[PMID 22392387] No association between the HTR1A gene and suicidal behavior: a meta-analysis.


GET Evidence
rs6295
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.516129
summary



[PMID 23192369] Relationship Between Genetic Polymorphisms in the HTR1A Gene and Paranoid Schizophrenia in a Northern Han Chinese Population


[PMID 23269215] Beyond Structural Equation Modeling: model properties and effect size from a Bayesian viewpoint. An example of complex phenotype - genotype associations in depression


[PMID 23798967OA-icon.png] No Effect of Serotoninergic Gene Variants on Response to Interpersonal Counseling and Antidepressants in Major Depression


[PMID 23499153] Genetic polymorphisms of serotonin transporter and receptor 1A could influence success during embryo implantation and maintenance of pregnancy


[PMID 23318131] Association of serotonin-1A and -2A receptor promoter polymorphisms with depressive symptoms, functional recovery, and pain in patients 6 months after lumbar disc surgery


[PMID 24158751] The effect of serotonin 1A receptor polymorphism on the cognitive function of premenstrual dysphoric disorder


[PMID 24304270] Regulatory variant of the TPH2 gene and early life stress are associated with heightened attention to social signals of fear in infants


[PMID 22727709] Evaluation of genetic models for response in a randomized clinical trial of duloxetine in major depressive disorder.


[PMID 22752684] The serotonin 1A receptor gene confer susceptibility to mood disorders: results from an extended meta-analysis of patients with major depression and bipolar disorder.


[PMID 22890315] Association between the 5-HT1A receptor gene polymorphism (rs6295) and antidepressants: a meta-analysis.


[PMID 23036158] The combined effects of the 5- HTTLPR and HTR1A rs6295 polymorphisms modulate decision making in schizophrenia patients.


[PMID 23333373] Rs6295 promoter variants of the serotonin type 1A receptor are differentially activated by c-Jun in vitro and correlate to transcript levels in human epileptic brain tissue.


[PMID 23375453] Genetic association of 5-HT1A and 5-HT1B gene polymorphisms with migraine in a Turkish population.


[PMID 23547754] Genetics of serotonin receptors and depression: state of the art.


[PMID 23733030] Pharmacogenetics in major depression: a comprehensive meta-analysis.


[PMID 25247748] Serotonin receptor gene (5-HT1A) modulates alexithymic characteristics and attachment orientation


[PMID 25990886] Impact of monoamine-related gene polymorphisms on hippocampal volume in treatment-resistant depression


[PMID 24021217OA-icon.png] Common selective serotonin reuptake inhibitor side effects in older adults associated with genetic polymorphisms in the serotonin transporter and receptors: data from a randomized controlled trial


[PMID 26544898] The impact of serotonin receptor 1A and 2A gene polymorphisms and interactions on suicide attempt and suicide risk in depressed patients with insufficient response to treatment - a European multicentre study


ClinVar
Risk rs6295(C;C)
Alt rs6295(C;C)
Reference rs6295(G;G)
Significance Drug-response
Disease paroxetine response - Efficacy
Variation info
Gene HTR1A
CLNDBN paroxetine response - Efficacy
Reversed 1
HGVS NC_000005.9:g.63258565C\x3d
CLNSRC PharmGKB Clinical Annotation PharmGKB
CLNACC RCV000211414.1,